Cysteine-richsecretoryprotein3isacysteine-richsecretoryproteinthatinhumansisencodedbytheCRISP3gene.CRISP3expressionisfoundinthesecretoryepitheliumthroughoutthemalegenitaltract,withparticularlyhighexpressioninthecaudaepididymisandampullavasdeferens.ItisapotentialbioMarkerforprostatecancer.CRISP3genecanbedefinedasanearly-transcribedgenewithaputativeroleinthepathophysiologyofsjogrenssyndrome.CRISP3ispresentinexocrinesecretionsandinsecretorygranulesofneutrophilicgranulocytesandisbelievedtoplayaroleininnateimmunity.