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LamininisalargebasementmembraneglycoproteincomposedofthreesubunitsdesignatedtheA,B1,andB2.Lamininhasdiversebiologicalfunctions,whichincludestimulatingepithelialcellgrowthanddifferentiation.ThenucleotidesequenceofhumanlamininAchainhasanopenreadingframeencoding3075-aminoacids.ThehumanlamininAchainisatlocus18p11.3.ThenucleotidesequenceofthehumanlamininB1revealsa5358-basepairopenreadingframethatpotentiallycodesfor1786aminoacids,including20aminoacidsofapresumptivesignalpeptide.Thegeneforthehumanlaminin-B1chainhasbeenlocalizedtochromosome7,bandq31.TheB2chainconsistsofsixdistinctdomains,includingtwodomainswithalpha-helical,coiled-coilstructures,twodomainswithcysteine-richhomologousrepeats,andtwoglobulardomains.TheaminoacidsequencesoftheB2andB1chainsdemonstrateconsiderablehomology.ThehumanlamininB2chaingenemapstothelongarmofchromosome1inthebandq31.