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Innovative Research/Human Kallikrein/IHKa/1mg

ProductDescription

HumanKallikrein

ActivationofPrekallikreinwithFactora-XIIaproducestheenzymaticallyactiveKallikrein.Kallikreinisaserineproteasewhichconsistsofaheavychain(Mr52kD)andlightchains(Mreither36or33kD)linkedbydisulfidebridges.KallikreinpossessesenzymaticactivitytowardFactorXII,HK,Plasminogen,FactorsXI,IX,andVII,proreninandthecomplementsystem.Afteractivation,theactivatingenzymeFactorXIIaisremovedbyaffinitychromatography.HumanKallikreinpurityisdeterminedbySDS-PAGEandshowscompletereductionuponincubationwith2-mercaptoethanol.

References:

(5-23-11)
CleavageofKininogenandSubsequentBradykininReleasebytheComplementComponent:Mannose-BindingLectin-AssociatedSerineProtease(MASP)-1

JDob,BMajor,KAKkesi,ISzab,MMegyeri...-PloSone,2011-dx.plos.org
...HumanKallikreinwaspurchasedfromCalbiochem(Darmstadt,Germany),orInnovativeResearch(Novi,MI):bothofthemwereaboutthesamegoodquality.Humanplasmakallikrein(referredtoaskallikrein)andhumanplasmaprekallikrein...

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