(+)Madindoline A

货号：	ALX-350-328-M001
保存条件：	-20
CAS号：	184877-64-3
供应商：	Neobioscience
规格：	1x1.0xmg

MadindolinesarenoncytotoxicindolealkaloidsoriginallyisolatedfromafermentationbrothofStreptomycesnitrosporeusK93-071.(+)-MadindolineA(MadA;MDL-A)and(+)-madindolineB(MadB;MDL-B)arediastereomerswithMadAbeingthemorepotentcompound.MadAbindscompetitivelybutnoncovalentlytotheextracellulardomainofthemembraneglycoproteingp130andinhibitsthehomodimerizationofthetrimericIL-6/IL-6R/gp130ortheIL-11/gp130complex,thusinhibitingactivationoftheJAK/STATsignaltransductionpathway.MadAinhibitsIL-6andIL-11-inducedosteoclastogenesisinvitroinadosedependentmannerandpostmenopausalosteoporosisinvivo,byamechanismdifferentfromthatof17β-estradiol.IL-6activityisknowntocausevariousdiseasessuchascancercachexia,Castleman’sdisease,Crohn’sdisease,rheumatoidarthritis,hypercalcemia,andmultiplemyeloma.Madindolinesarenolongeravailablefromnaturalsourcesduetomutationoftheoriginatingbacterialstrain.Thus,syntheticrouteshavebeendevelopedtoproducemadindolines.AnalogsofmadindolineshavebeensynthesizedaspotentIL-6inhibitors.