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The 22D1 monoclonal antibody reacts with mouse CD209b also known as SIGN-R1. CD209b is a 37 kDa type II transmembrane C-type lectin receptor. CD209b is expressed on the surface of splenic marginal zone and lymph node medullary macrophages and is commonly used as a marker for these cells. The CD209b protein is involved in the innate immune response, it binds to and initiates uptake of various microorganisms by recognizing high-mannose-containing glycoproteins on their envelopes. The 22D1 antibody has been reported to block CD209b in vivo.
| Isotype | Armenian Hamster IgG, κ |
| Recommended Isotype Control(s) | InVivoMAbpolyclonal Armenian hamster IgG(BE0091) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
| Immunogen | C-terminal peptide of mouse SIGN-R1 |
| Reported Applications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 μM filtered |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| RRID | AB_2687704 |
| Molecular Weight | 150 kDa |
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