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The OX-90 monoclonal antibody reacts with mouse CD200 also known as OX2. CD200 is a type 1 membrane glycoprotein belonging to the immunoglobulin superfamily. CD200 expression is limited to thymocytes, neurons, B cells, splenic follicular dendritic cells and endothelium, and subsets of T cells and dendritic cells. CD200 has been shown to co-stimulate T cell proliferation. It is thought that engagement of CD200 with its receptor, CD200R, results in inhibition and/or downregulation of myeloid cell activity. Blocking this interaction decreases the inhibitory thresholds of myeloid cells resulting in increased immune activity. The OX-90 antibody has been reported to block the binding of CD200 to CD200R in vivo.
| Isotype | Rat IgG2a, κ |
| Recommended Isotype Control(s) | InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089) |
| Recommended InVivoPure Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer(IP0070) |
| Immunogen | Fusion protein consisting of mouse CD200 (extracellular region) and rat CD4 (domains 3 and 4) |
| Reported Applications |
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| Endotoxin |
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| Purity |
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| Formulation |
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| Sterility | 0.2 μm filtration |
| Production | Purified from tissue culture supernatant in an animal free facility |
| Purification | Protein G |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
| RRID | AB_2687821 |
| Molecular Weight | 150 kDa |
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