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Antibodies > Molecular Biology/Cell Biology
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anti-Prion protein antibodymouse monoclonal (7A1)
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Code:65-903 Prion protein PrP is a membrane glycosylphosphatidylinositol(GPI) anchored glycoprotein highly expressed in neuron and glia cells as well as immune and reproductive cells.Mutations in the octapeptide repeat regions as well as elsewhere in this gene have been associated with neurodegenerative diseases such as Creutzfeldt Jakob disease fatal familial insomnia Gerstmann Straussler disease Huntington disease like 1 and kuru.The infectious isoform of PrPC known as PrPSc is able to convert normal PrPC proteins into the infectious isoform which is insoluble amyloid aggregate by changing their conformation (1).Mature PrP protein in human consists of 209 amino acids.Several topological forms exist; one cell surface form anchored via glycolipid and two transmembrane forms which are responsible for appearance of multiple bands in SDS-PAGE (Figure).　Applications1) Western blotting (~0.5 μg/ml)2) ELISAOther applications have not been tested. 　
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65-903
50 μg
210USD
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