The choroid plexus is a plexus of cells that produces the cerebrospinal fluid in the ventricles of the brain. It consists of a layer of cuboidal epithelial cells surrounding a core of capillaries and loose connective tissue. Choroid plexus participates in brain development, maturation, aging, endocrine regulation, neuroimmune interactions, and pathogenesis of certain neurodegenerative diseases. The choroid plexus consists of a network of capillaries enclosed by a single layer of epithelial cells; that together form the blood-CSF barrier. Human Choroid Plexus Epithelial Cells (CPEpiC) respond to ischemic and traumatic insults in the central nervous system by synthesizing and secreting various growth factors and peptides with trophic benefits that work through autocrine and paracrine mechanisms to facilitate recovery. CPEpiC cultures serve as an excellent model to study the exchange processes across blood-CSF barrier, CSF homeostasis, and more.
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