L-Homopropargylglycine(HPG)isanaminoacidanalogofmethioninethatcontainsaverysmallmodification,specificallyanalkynemoietythatcanbefedtoculturedcellsandincorporatedintoproteinsduringactiveproteinsynthesis.Detectionutilizesthechemoselectiveligationor“click”reactionbetweenanazideandanalkyneorcyclooctyne.Thealkyne-modifiedproteinisdetectedwitheitherfluorescentazideorbiotinazide.Detectionsensitivitywiththesereagentsin1-DgelsandWesternblotsisinthelowfemtomolerangeandcompatIBLewithdownstreamLC-MS⁄MSandMALDIMSanalysis.

| Molecularweight | 163.60(HClsalt) |
| Chemicalcomposition | C6H10ClNO2 |
| CAS | 98891-36-2 |
| Solubility | Water,DMSO,DMF |
| Purity | >95%(HNMR) |
| Appearance | Whitecrystalline |
| Storageconditions | -20C |
| Shippingconditions | Ambienttemperature |