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| AlternativeName: | Discoveredongastrointestinalstromaltumorsprotein1,ANO1,Anoctamin-1,TMEM16A,Transmembraneprotein16A |
| Clone: | DG1/1487R |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | RecombinantfulllengthhumanDOG1. |
| UniProtID: | Q5XXA6 |
| Gene/ProteinIdentifier: | 55107(GeneID) |
| Speciesreactivity: | Human |
| Applications: | FlowCytometry,IF,IHC(PS) |
| RecommendedDilutions/Conditions: | FlowCytometry(0.5-1µg/106cellsin0.1mL) Immunofluorescence(0.5-1µg/mL) Immunohistochemistry(formalin-fixedparaffinsections)(0.25-0.5µg/mL)for30minutesatRT Suggesteddilutions/conditionsmaynotbeavailableforallapplications. Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| PurityDetail: | ProteinGaffinitypurified. |
| Formulation: | Liquid.In1XPBScontaining0.1mg/mlBSA(USsourced)and0.05%sodiumazide. |
| Shipping: | ShippedonBlueIce |
| LongTermStorage: | +4°C |
| ScientificBackground: | ExpressionofDOG-1proteiniselevatedinthegastrointestinalstromaltumors(GISTs),c-kitsignaling-drivenmesenchymaltumorsoftheGItract.DOG-1israrelyexpressedinothersofttissuetumors,which,duetoappearance,maybedifficulttodiagnose.ImmunoreactivityforDOG-1hasbeenreportedin97.8%ofscorableGISTs,includingallc-kitnegativeGISTs.OverexpressionofDOG-1hasbeensuggestedtoaidintheidentificationofGISTs,includingplatelet-derivedgrowthfactorReceptorαmutantsthatfailtoexpressc-kitantigen.TheoverallsensitivityofDOG1andc-kitinGISTsisnearlyidentical:94.4%vs.94.7%. |
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