LKT/MOXIFLOXACIN HYDROCHLORIDE/M5794/100 mg188bio精品生物—专注于实验室精品爆款的电商平台

ProductIDM5794

CasNo.186826-86-8

Purity≥98%

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Description

Moxifloxacinisafluoroquinoloneantibioticcommonlyusedtotreatocularinfectionssuchasbacterialconjunctivitisaswellassinusandlunginfectionssuchaspneumonia.Moxifloxacindisplaysantibacterialefficacyagainstbothgramnegativeandgrampositivebacteria,preventingDNAsynthesisinbacterialpathogensbyinhibitingtopoisomeraseIVandbacterialDNAgyrase.ThiscompoundiscurrentlybeingexaminedasaconjunctivetherapywithanticanceragentsagainstseveralformsofcancerduetoitstopoisomeraseIIinhibition.Combiningmoxifloxacinwithanticanceragentsyieldsacytotoxicdrugsparingeffectduetothesynergismofthemechanismsofactionbetweenmoxifloxacinandtheanticancerdrugs.

ProductInfo

CasNo.	186826-86-8
Purity	≥98%
Formula	C₂₁H₂₄FN₃O₄•HCl
FormulaWt.	437.89
ChemicalName	1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylicacidhydrochloride
IUPACName	7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylicacid;hydrochloride
Synonym	Actura;Avalox;Avelox;Octegra;Proflox
MeltingPoint	324-325°C
Solubility	Solubleinwater(2.4g/100ml).Methanol,DMSO
Appearance	Almostwhitetoyellowishcrystallinepowder

ShippingandStorage

StoreTemp	4°C
ShipTemp	Ambient

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MSDS	M5794MSDSPDF
InfoSheet	M5794InfoSheetPDF

References

WohlkonigA,ChanPF,FosberryAP,etal.StructuralbasisofquinoloneinhibitionoftypeIIAtopoisomerasesandtarget-mediatedresistance.NatStructMolBiol.2010Sep;17(9):1152-3.PMID:20802486.

ReuveniD,HalperinD,ShalitI,etal.Moxifloxacinenhancesetoposide-inducedcytotoxic,apoptoticandanti-topoisomeraseIIeffectsinahumancoloncarcinomacellline.IntJOncol.2010Aug;37(2):463-71.PMID:20596674.

ReuveniD,HalperinD,FabianI,etal.Moxifloxacinincreasesanti-tumorandanti-angiogenicactivityofirinotecaninhumanxenografttumors.BiochemPharmacol.2010Apr15;79(8):1100-7.PMID:20025849.

LaponogovI,SohiMK,VeselkovDA,etal.Structuralinsightintothequinolone-DNAcleavagecomplexoftypeIIAtopoisomerases.NatStructMolBiol.2009Jun;16(6):667-9.PMID:19448616.

StromanDW,DajcsJJ,CuppGA,etal.Invitroandinvivopotencyofmoxifloxacinandmoxifloxacinophthalmicsolution0.5%,anewtopicalfluoroquinolone.SurvOphthalmol.2005Nov;50Suppl1:S16-31.PMID:16257308.

AldredKJ,McPhersonSA,WangP,etal.DruginteractionswithBacillusanthracistopoisomeraseIV:biochemicalbasisforquinoloneactionandresistance.Biochemistry.2012Jan10;51(1):370-381.PMID:22126453.

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LKT/MOXIFLOXACIN HYDROCHLORIDE/M5794/100 mg

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