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IBL/Herpes simplex virus 1/2 IgG ELISA/RE56471/

Kitsize96
MethodELISA
Incubationtime1x1h,1x30min,1x20min
Standardrange1-200U/ml
Specimen/Volumes5µlSerum,Plasma
Substrate/isotopeTMB450nm
RegulatoryStatus:EU:CE
Detailsfor: Herpessimplexvirus1/2IgGELISA
TheHerpessimplexvirusestype1and2areubiquitouspathogensofhumansthatusuallycauseeitherasymptomaticinfectionormildskinandmucosaldiseases.HSV1causes85%andHSV215%oforalprimaryinfections.HSV1causesdifferentclinicalsymptomsinabout10%oftheprimaryinfectionslikegingivostomatitis,keratitis,conjunctivitis,vesiculareruptionsoftheskin,encephalitis,eczemaandsomeletalinfectionsofnewborns.PersonsatanincreasedriskforseriousorprolongedHSVinfectionsarethosewitheczema,severeburnsoradefectintheircell-mediatedimmunity.
HSV2maycauseothersymptomsliketheHerpesgenitalissyndromeoccurringprincipallyinadults.Theprecedingprimaryinfectionwillbetransmittedviasexualcontact.HSV2isavirussUSPectedtoinducecervixcarcinomainwomen.InsomecasesaHSV2causedmeningitisoccursthatismuchmilderthanaHSV1causedencephalitis.ThemostseverecomplicationofgenitalHSVinfectionistheneonataldisease.
DiagnosisoftheprimaryinfectionbyHSV1/HSV2canbeconfirmedbyasignificantriseoftheIgGtiterwithin6to10days.AfinishedinfectioncanbemonitoredwiththeIgGELISA.IncaseofasuspicionofHSVencephalopathyitisrecommendedtoperformaparalleldeterminationofbothHSV-specificantibodies(IgGandIgM)inserumandliquor.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
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