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Adipogen/CCT244747/SYN1216M050/50 mg
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ProductDetails
Synonyms(R)-3-((1-(Dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile
ProductTypeChemical
Properties
FormulaC20H24N8O2
MW408.5
CAS1404095-34-6
PurityChemicals≥95%
AppearanceSolid.
SolubilitySolubleinDMSO.
DeclarationManufacturedbySynKinase.
OtherProductDataTarget:CHK1|KinaseGroup:CAMK|Substrate:Serine-Threonine

ClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
InChiKeyIENLGMOXAQMNEH-CYBMUJFWSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StabilityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
CCT244747isanovel,potent,highlyselective,orallyactive,ATPcompetitiveCHK1inhibitor.CCT244747caninhibitcellularCHK1activitywithanIC50of29-170nM.Inmultipletumourcellmodels,thishastheeffectofsignificantlyenhancingthecytotoxicityofseveralanticancerdrugs(suchasgemcitabineandirinotecan)andabrogatingdrug-inducedSandG2arrest.
ProductReferences
  1. Discoveryof3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitrilesasselective,orallybioavailableCHK1inhibitors:M.Lainchbury,etal.;J.Med.Chem.55,10229(2012)
  2. CCT244747isanovelpotentandselectiveCHK1inhibitorwithoralefficacyaloneandincombinationwithgenotoxicanticancerdrugs:M.I.Walton,etal.;Clin.CancerRes.18,5650(2012)

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