Deprecated: Required parameter $cat_id follows optional parameter $type in /www/wwwroot/ebimall.com/systems/hong.php on line 2088

Deprecated: Required parameter $where follows optional parameter $tree_id in /www/wwwroot/ebimall.com/systems/hlb.php on line 3505
LKT/MOXIFLOXACIN FREE BASE/M5793/1 g188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
您好,欢迎您进入188进口试剂采购网网站! 服务热线:4000-520-616
蚂蚁淘商城 | 现货促销 | 科研狗 | 生物在线

LKT/MOXIFLOXACIN FREE BASE/M5793/1 g
ProductIDM5793
CasNo.151096-09-2
Purity≥98%
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

Moxifloxacinisafluoroquinoloneantibioticcommonlyusedtotreatocularinfectionssuchasbacterialconjunctivitisaswellassinusandlunginfectionssuchaspneumonia.Moxifloxacindisplaysantibacterialefficacyagainstbothgramnegativeandgrampositivebacteria,preventingDNAsynthesisinbacterialpathogensbyinhibitingtopoisomeraseIVandbacterialDNAgyrase.ThiscompoundiscurrentlybeingexaminedasaconjunctivetherapywithanticanceragentsagainstseveralformsofcancerduetoitstopoisomeraseIIinhibition.Combiningmoxifloxacinwithanticanceragentsyieldsacytotoxicdrugsparingeffectduetothesynergismofthemechanismsofactionbetweenmoxifloxacinandtheanticancerdrugs.

ProductInfo

CasNo.

151096-09-2

Purity

≥98%

Formula

C21H24FN3O4

FormulaWt.

401.43

IUPACName

7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylicacid

Appearance

YellowSolid

ShippingandStorage

StoreTemp

4°C

ShipTemp

Ambient

Downloads

MSDS

M5793MSDSPDF

InfoSheet

M5793InfoSheetPDF

References

WohlkonigA,ChanPF,FosberryAP,etal.StructuralbasisofquinoloneinhibitionoftypeIIAtopoisomerasesandtarget-mediatedresistance.NatStructMolBiol.2010Sep;17(9):1152-3.PMID:20802486.

ReuveniD,HalperinD,ShalitI,etal.Moxifloxacinenhancesetoposide-inducedcytotoxic,apoptoticandanti-topoisomeraseIIeffectsinahumancoloncarcinomacellline.IntJOncol.2010Aug;37(2):463-71.PMID:20596674.

ReuveniD,HalperinD,FabianI,etal.Moxifloxacinincreasesanti-tumorandanti-angiogenicactivityofirinotecaninhumanxenografttumors.BiochemPharmacol.2010Apr15;79(8):1100-7.PMID:20025849.

LaponogovI,SohiMK,VeselkovDA,etal.Structuralinsightintothequinolone-DNAcleavagecomplexoftypeIIAtopoisomerases.NatStructMolBiol.2009Jun;16(6):667-9.PMID:19448616.

StromanDW,DajcsJJ,CuppGA,etal.Invitroandinvivopotencyofmoxifloxacinandmoxifloxacinophthalmicsolution0.5%,anewtopicalfluoroquinolone.SurvOphthalmol.2005Nov;50Suppl1:S16-31.PMID:16257308.

AldredKJ,McPhersonSA,WangP,etal.DruginteractionswithBacillusanthracistopoisomeraseIV:biochemicalbasisforquinoloneactionandresistance.Biochemistry.2012Jan10;51(1):370-381.PMID:22126453.


新闻动态
行业前沿
技术文章
最新产品

188进口试剂采购网 www.188bio.cn -中国试剂网,试剂网,化学试剂网,国药试剂,抗体公司,试剂公司,试剂盒公司,苏州试剂公司,北京化学试剂公司,天津化学试剂,试剂商城,试剂代理,流式抗体 细胞库查询 sitemap