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Cellgs/BIRB796/BIRB796, 10 mg/SM11-10

ExactAmount™

Themgquantityofmaterialprovidedinthesmallestpacksizeforthisproductisspecifiedontheviallabeltotwodecimalplaces.Thisreducesconcentrationvariationandensuresreproducibilityinyourexperiments.

Activity

BIRB796isaproteinkinaseinhibitorofp38MAPK.BIRB796hashighpicomolaraffinityforp38MAPkinaseandlownanomolarinhibitoryactivityagainstTNF-alphainTHP-1cellculture.Thep38inhibitorBIRB796bindstightlytoABL(T315I)andinhibitstheBMS-354825andimatinib-resistantABL(T315I)kinase.

Effect

BIRB796hasbeenusedaspartofthenaivehumanstemcell(NSHM)mediumtocreatenaivestatehumancells.

AlternativeNames

Doramapimod,BIRB-796,BIRB796,285983-48-4,S1574_Selleck,Kinome_2137,1kv2,UNII-HO1A8B3YVV,Doramapimod(USAN/INN)

1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naphthalen-1-yl]urea

References

1.Gafni,O.,etal.2013.Nature.504(7479):282-286.PMID:24172903

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ProductDetails
FormulaC31H37N5O3
MolecularWeight527.66
CASNumber285983-48-4
Purity>99%
SolubilityDMSO,ethanol
StABIlityandStorageStableat-20°C.Keepawayfromdirectsunlight.

Documents

SM11Datasheet.pdfSM11MSDS.pdf

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