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Diagnostic BioSystems/Adenovirus/MOB355R/Concentrated 1 ml

  • CloneM58+M73
  • IsotypeM58,IgG2a,kappa;M73,IgG2a,kappa
  • ImmunogenBALB/Cmicewereinjectedwithadenovirus.
  • SummaryThisantibodyreactswithadenovirus.TheadenovirusearlygeneproductE1Aisapotentstimulatorofcellularproliferation,whichwhenoverexpressedcanovercomethegrowth-inhibitoryeffectsofTGF-β.TheE1Aregionencodesaseriesofrelatedproteins(35-46kDa)withmultifunctionalcapABIlitiesandformsaspecificcomplexwiththeretinoblastomatumorsuppressorgeneproduct.TheE1AandE1Bregionstogethercomprisethetransformingregionofadenovirus.WhileexpressionofE1Aaloneissufficienttoimmortalizeprimarycells,completetransformationrequirestheadditionalexpressionoftheE1Bregion.
  • CellularLocalizationNuclear
  • PositiveControlTissueAdenovirusinfectedtissue
  • IntendedUseRUO
  • Description/TypeMonoclonalMouseAnti-Human
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