Non-competitive irreversible protein tyrosine phosphatases (PTP) inhibitor (Ki = 1.2 µM for PTP-1B). Inhibits a broad spectrum of PTPs (IC50 values are 0.9, 1.7, 0.09, 1.5 and 0.7 µM for PTP-1B, TCPTP, SHP-2, LAR and YopH respectively). Inhibits several cytochrome P450 isoforms and suppresses MMP-9 and blocks TPA-induced NF-κB activation. Exhibits no activity for MAPK. Enhances insulin sensitivity. Cell permeable.
Biological action
Inhibitor
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Properties
Molecular Weight
241.25
Chemical structure
Molecular Formula
C14H11NO3
CAS Number
39674-97-0
PubChem identifier
6604934
SMILES
CC1(C2=C(C3=CC=CC=C3C(=O)C2=O)NC1=O)C
Storing and Using Your Product
Storage instructions
room temperature
Solubility overview
soluble in ethanol or DMSO (50mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References for BVT 948
Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione.
Liljebris C et al (2004)J Pharmacol Exp Ther 309(2) : 711-9.
PubMedID: 14747616
Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9.
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