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Hello Bio/NPC-15437 dihydrochloride/HB0457/50mg

Productoverview

  • Name
    NPC-15437dihydrochloride
  • Shortdescription
    Competitive,selectivePKCinhibitor
  • BIOLOGicaldescription
    CompetitiveandselectiveproteinkinaseC(PKC)inhibitor(IC50=19.0µM)thatinteractsatNterminalofC1domain.ShowsselectivityforPKC-αoverPKC-HHandPKC-CB(IC50valuesare22,30,130µMrespectively).ExhibitslittleornoactivityforcAMP-dependentorcalcium/calmodulin-dependentproteinkinase(IC50values>300µM).Displaysneuroprotectiveproperties.
  • Biologicalaction
    Inhibitor
  • Ourproductsinaction
    SubmitYourCitationNow

Properties

  • MolecularWeight
    511.62
  • Chemicalstructure
    NPC-15437 dihydrochloride [136449-85-9]
  • MolecularFormula
    C25H50N4O2.2HCl
  • CASNumber
    136449-85-9
  • PubChemidentifier
    16219723
  • SMILES
    CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@H](CCCCN)N.Cl.Cl

StoringandUsingYourProduct

  • Storageinstructions
    +4°C
  • Solubilityoverview
    solubleinwaterorDMSO
  • Important
    ThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.

ReferencesforNPC-15437dihydrochloride

  • 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide(NPC15437):aselectiveinhibitorofproteinkinaseC.

    SullivanJPetal(1991)AgentsActions34(1-2):142-4.
    PubMedID:1793019

  • 2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanamide(NPC15437):anovelinhibitorofproteinkinaseCinteractingattheregulatorydomain.

    SullivanJPetal(1992)MolPharmacol41(1):38-44.
    PubMedID:1732721

  • NPC15437interactswiththeC1domainofproteinkinaseC.AnanalysisusingmutantPKCconstructs.

    SullivanJPetal(1991)FEBSLett285(1):120-3.
    PubMedID:2065775

  • TheselectiveproteinkinaseCinhibitor,NPC15437,inducesspecificdeficitsinmemoryretentioninmice.

    MathisCetal(1992)EurJPharmacol220(1):107-10.
    PubMedID:1425976
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