Hello Bio/Ro 256981 maleate/HB0554/10mg

Name
Ro 25-6981 maleate
Short description
Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
Biological description
Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs.
Exhibits >5000-fold selectivity at GluN1C-GluN2B over GluN1C-GluN2A (IC₅₀ values are 9 nM and 52 µM). Shows neuroprotective properties.
Biological action
NAM
Purity
>98%
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Chemical name
(αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4- (phenylmethyl)-1-piperidinepropanol maleate
Molecular Weight
455.55
Chemical structure
Molecular Formula
C₂₂H₂₉NO₂.C₄H₄O₄
CAS Number
1312991-76-6
PubChem identifier
53250677
SMILES
C[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O.C(=CC(=O)O)C(=O)O
Source
Synthetic
InChi
InChI=1S/C22H29NO2.C4H4O4/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;5-3(6)1-2-4(7)8/h4-10,17,19,22,24-25H,11-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,22+;/m0./s1
InChiKey
FYJZEHCQSUBZDY-SEELMCCHSA-N
MDL number
MFCD06798375
Appearance
White solid

Storage instructions
Room temperature (desiccate)
Solubility overview
Soluble in water (10mM, gentle warming) and in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.
Fischer G et al (1997)J Pharmacol Exp Ther 283(3) : 1285-92.
PubMedID: 9400004
The NR2B-selective N-methyl-D-aspartate receptor antagonist Ro 25-6981 [(+/-)-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propanol] potentiates the effect of nicotine on locomotor activity and dopamine release in the nucleus
Kosowski AR et al (2004)J Pharmacol Exp Ther 311(2) : 560-7.
PubMedID: 15256539
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.
Lynch DR et al (2001)Eur J Pharmacol 416(3) : 185-95.
PubMedID: 11290368

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