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MD Bioproducts/ArthritoMab™ Antibody Cocktail for C57BL/6/50 mg/CIA-MAB-2C188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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MD Bioproducts/ArthritoMab™ Antibody Cocktail for C57BL/6/50 mg/CIA-MAB-2C

Overview
Overview:

Collagen-induced arthritis (CIA) in mice is widely used as an experimental model for rheumatoid arthritis (RA) in humans. CIA is mediated by autoantibodies, which bind to a particular region of type II collagen (CII). The ability to induce arthritis using this arthritogenic antibody cocktail provides an efficient protocol for the induction of antibody-mediated arthritis that can be used as a shorter, more synchronized alternative to the CIA model.

Benefits of the CAIA model

  • Length of study: Arthritis develops in mice typically within 24-48 hr allowing the completion of a study within 2 weeks reducing the number of assessments and scoring periods.
  • Reduced group size: Rate of incidence is nearly 100% depending on the strain allowing for smaller group sizes.
  • Synchronization: onset of disease is synchronized between animals simplifying treatment schedules.
  • Steady & Controlled Disease Progression: evaluate various regimes with a steady disease progression. No rapid & severe disease spikes to contend with.
  • Susceptibility: Induce arthritis in transgenic strains with as little as 2 mg of Antibody.

ArthritoMab antibody cocktail for induction in C57Bl/6 strains

Comparison

ArthritoMab™Competitor

Epitopes Recognized

CB11, CB10, CB8CB11 only
Disease ProgressionSteady & ControlledRapid & Severe
Paw involvementConsistent & Predominantely rearVariable & unpredictable
Amount required for C57Bl/62 mg (25 animals per vial)5 mg (8 animals per vial)

Abreviations:

  • Anti-Collagen Induced arthritis (ACIA)
  • Monoclonal Antibody induced arthritis (mAb-RA)
  • Collagen Antibody Induced Arthritis (CAIA)

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