QED Bioscience/Tolllike Receptor 8 (TLR8)/56508/1 Ea

productdatasheet

CatalogNo.:56508

Size:50ugpurifiedbyantigenaffinitychromatographyinPBScontaining0.01%sodiumazide.Concentrationis1mg/ml.

TLR8isa1,041aaproteincontaining26N-terminalleucine-richrepeatmotifs(LRRs)withamolecularweightof120kDa.TLR8ismostcloselyrelatedtoTLR7andTLR9with43%and35%overallaasequenceidentity,respectively.Invivo,TLR8mRNAisexpressedinlung,placenta,spleen,lymphnode,bonemarrow,andPBLs,withhighestexpressionfoundinmonocytes.TLR8mayalsobelocalizedintracellularlyand,likeTLR7,bindsimidazoquinolineswhilethenaturalligandsarestillunknown.

Antigen:SyntheticpeptidecorrespondingtoaninternalregionofhumanTLR8.

HostSpecies:Rabbit

AntibodyClass:Polyclonal

Preservatives:0.01%sodiumazide

ThisantibodyrecognizeshumanandmouseTLR8.

Westernblotting:useat1:500-1:2,000.Abandofapproximately120kDaisdetected.ELISA:useat1:2,000-1:10,000.

Immunohistochemistry:formalin-fixed,paraffin-embeddedtissues,useat5ug/ml.

Lung,alveolarmacrophages:Formalin-fixedparaffin-embedded

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Storeat4oC(short-term)or-70oC(long-term).

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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