QED Bioscience/Tolllike Receptor 1 (TLR1)/56501/1 Ea

productdatasheet

CatalogNo.:56501

Size:50ugpurifiedbyion-exchangechromatographyinPBScontaining0.02%sodiumazide.

TLR1isa786aminoacidproteinwith18N-terminalleucine-richrepeatmotifs(LRRs)andacalculatedmolecularweightof84kDa.TLR1ismostcloselyrelatedtoTLR6andTLR10with68%and48%overallsequenceidentity,respectively.Invivo,twodifferentsizedtranscriptsforTLR1areobservedsuggestingthatthemRNAisalternativelysplicedtogeneratetwodifferentformsoftheprotein.TLR1mRNAisubiquitouslyexpressedandfoundathigherlevelsthantheotherTLRs.Ofthemajorleukocytepopulations,TLR1ismosthighlyexpressedbymonocytes,butisalsoexpressedbymacrophages,dendriticcells(DCs),polymorphonuclearleukocytes,B,T,andNKcells.

Antigen:Syntheticpeptidecorrespondingto16aminoacidsneartheaminoterminusofhumanTLR1.

HostSpecies:Rabbit

AntibodyClass:Polyclonal

Preservatives:0.02%sodiumazide

ThisantibodyrecognizeshumanandmouseTLR1.

Westernblotting:useat1-2ug/ml.Abandofapproximately84kDaisdetected.

Immunohistochemistry:formalin-fixed,paraffin-embeddedtissues,useat5ug/ml.

Smallintestine:Formalin-fixedparaffin-embedded

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableat4oC(short-term)or

-70oC(long-term).

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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