QED Bioscience/BAFFR/BR3 (CT)/40204/1 Ea

productdatasheet

CatalogNo.:40204

Size:100ugIgGin100ulPBS,pH7.4,purifiedbyimmunoaffinitychroma-tography.

MembersoftheTNFsuperfamilyareinvolvedinregulationofimmuneresponsesandinductionofapoptosis.AnovelmemberoftheTNFsuperfamily,BAFF/BlyShasbeencharacterizedasaBcellactivatorsinceitstimulatesBcellproliferationandimmunoglobulinsecretion.TworeceptorsforBAFF(TACIandBCMA)werefirstidentified.AthirdreceptorwasrecentlyidentifiedanddesignatedBAFF-RandBR3forBlySreceptor3.

BAFF-RisspecificforBAFFandplaysamajorroleinBAFF-inducedBcelldevelopmentandsurvival.BAFFanditsreceptorsareinvolvedinBcellassociatedautoimmunediseasesandactivateNF-κBandc-junN-terminalkinase.

Antigen:Peptidecorrespondingtoaa169-183attheC-terminusofhumanBAFF-R.

HostSpecies:Rabbit

Stabilizers:None

Preservatives:0.02%sodiumazide.

Thisantibodyrecognizeshuman,mouse,andratBAFF-R.

Immunoblotting:useat2-5ug/ml.Positivecontrol:human,mouse,orratspleentissuelysates.

Immunohistochemistry:useat5ug/ml.Positivecontrol:humantonsil.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforone(1)yearat4oCor-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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