QED Bioscience/Yersinia pestis V Antigen/18775200/1 Ea

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YersiniapestisVAntigenMonoclonalAntibodies

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Format:TheseantibodiesarepurifiedbyProteinGaffinitychromatographyandaresuppliedinPBS,pH7.4,containing0.1%sodiumazideaspreservative.

Y.pestis,thecausativeagentofplague,haslow-Ca+2response(LCR)virulenceplasmidsthatencodeasetofsecretedvirulenceproteinsincludingYersiniaouterproteins(YOPS)andtheVantigen,LcrV.SomeoftheYOPSplayaroleinadherencetoeukaryoticcellswhileothersaretargetedintoaeukaryoticcellatthesiteofadherence.TheYOPSderangecellularsignalingandcytoskeletalfunctionsnecessaryforhostdefensessuchasphagocytosis.LcrVisasecretedanti-hostcomponentwithdirectimmunomodulatoryeffects.LcrVexpressionisinvolvedintargetingofYOPStohostcellsandisrequiredforcytotoxicity.

Antigen:Recombinantfull-length

Y.pestisVantigen.

HostSpecies:MouseAntibodyClass:AllareIgG1.Preservative:0.1%NaN3

Theseantibodiesspecificallyrecognize

Y.pestisVantigen.Theydonotcross-reactwithY.pestiscapsularF1antigen.

Immunoblotting:End-usershoulddetermineoptimalconcentration.Werecommendtestingaconcentrationrangeof1-10ug/ml.Abandof37kDaisdetected.

ELISA:End-usershoulddetermineoptimalconcentrationfortheirsample.SandwichELISA:use18772ascoatingantibodyand18773asdetectantibody.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableforatleastone

(1)yearat4oCor-20oC.Avoidmultiplefreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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