QED Bioscience/EAAC1/56520/1 Ea

CatalogNo.:56520(cloneS180-41)Size:100uginPBS(1mg/ml),pH7.4,50%glycerol,0.09%sodiumazide.

PurifiedbyProteinGaffinitychromatography.

Excitatoryamino-acidcarrier1(EAAC1)isahigh-affinityNa+-dependentL-glutamate/D,L-aspartatecellmembranetransportprotein.Itisexpressedinbrain

aswellasinseveralnon-nervoussystemtissues.Inbrain,EAAC1istheprimaryneuronalglutamatetransporter.Ithasapolarizeddistributionincellsandfunctionsmainlyperisynapticallytotransportglutamatefromtheextracellularenvironment.Inthekidneyitisinvolvedinrenalacidicaminoacidreabsorptionandaminoacidmetabolism.EAAC1-associatedproteinGTRAP3-18maybeimportantinregulatingthemetabolicfunctionofEAAC1.

Antigen:Fusionproteincorrespondingtoaa1-524(full-length)ofhumanEAAC1(accessionno.NP_004161.4).

HostSpecies:Mouse

AntibodyClass:IgG1

ThisantibodyrecognizeshumanEAAC1.

Immunoblotting:useat1-5ug/ml.Abandof~60kDaisdetected.

Immunoblotonratbrainmembranes.

Thesearerecommendedconcentrations.Endusershoulddetermineoptimalconcentrationsfortheirapplications.

Positivecontrol:ratbrainmembranes.

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisproductisstableforatleast1yearat

-20oC.Freezeinmultiplealiquotstoavoidrepeatedfreeze-thawcycles.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.