QED Bioscience/Sphingosine Kinase type 1/13810/1 Ea

productdatasheet

CatalogNo.:13810

Size:50ugpeptideimmunogenaffinitypurifiedantibodyinPBScontaining0.1%sodiumazide.

Sphingosinekinase(SPHK)phosphorylatessphingosinetoformabioactivelipid,sphingosine1-phosphate(S1P).S1Pisanovellipidmessengerwithbothintracellularandextracellularfunctions.Intracellularly,itregulatesproliferationandsurvivalwhileextracellularlyitisaligandforendothelialdifferentiationgene1(EDG1).ExpressionofSPHK1andsubsequentproductionofS1PpromotestheG1-Stransition,protectscellsfromapoptosis,stimulatesmigrationandangiogenesis,andinducestumorformationinmice.

Antigen:SyntheticpeptideconjugatedtoKLH.

HostSpecies:Rabbit

Preservatives:0.1%sodiumazide

ThisantibodyrecognizesanepitopewithintheN-terminaldomainofhumanSPHK1.

Immunohistochemistry:Useat10ug/ml.

Adrenal,pheochromocytes:Formalin-fixed,paraffin-embedded

DiluteinPBSormediumwhichisidenticaltothatusedintheassaysystem.

Thisantibodyisstableat4oC(short-term)and-70oC(long-term).

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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