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ORDERINGINFORMATION
CatalogNos.:3330(clone75),3345(clone325),and3346(clone306).Format:100ugpurifiedantibodyin10mMTrisbuffer,pH7.5,0.15MNaCL,0.05%sodiumazide.Purifiedbyionexchangechromatography.BACKGROUND
CA-125(cancerantigen125,carcinomaantigen125,orcarbohydrateantigen125)alsoknownasmucin16orMUC16isencodedbytheMUC16geneinhumans.MUC16isamemberofthemucinfamilyofglycoproteins.CA-125ismostconsistentlyelevatedinepithelialovariancancer,butcanbeexpressedinanumberofgynecologic(endometrial,fallopiantube)andnon-gynecologic(pancreatic,breast,colonandlung)cancers.Itmayalsobeelevatedincasesofbenignabnormalitiessuchasendometriosis.
SPECIFICATIONSUMMARY
Antigen:CA-125purifiedfromovariancarcinomacells.HostSpecies:MouseAntibodyClass:IgG1Specificity:#3330and#3345epitopespecificitygroupB(ISOBM*classification).#3346epitopespecificitygroupA(ISOBM*classification)
*InternationalSocietyofOncologyandBioMarkers
APPLICATIONS
TheseantibodiesmaybeusedinELISAandWesternblottingtodetectCA-125.
Positivecontrol:OVCAR3ovarianadenocarcinomacells.
SuggestedpairsforsandwichELISA:CaptureDetection
#3346#3345
#3346#3330
#3345maybeusedinimmunohistochemistryonparaffin-embeddedsamples.
LungadenocarcinomaSerosalovarianBladderadenocarcinoma
adenocarcinoma
DILUTIONINSTRUCTIONS
DiluteinPBSormediumthatisidenticaltothatusedintheassaysystem.
STORAGEANDSTABILITY
Theseantibodiesarestableforatleastone(1)yearat-20oC.Avoidmultiplefreeze-thawcycles.
Forinvitroinvestigationaluseonly.Notintendedfortherapeuticordiagnosticapplications.