QED Bioscience/Recombinant Human Cardiac Troponin I (TnI)/24001P10/1 Ea

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Formulation:Sterile-filteredsolutionin50mMTris,pH8.0and6Murea.

Purifiedbyproprietarychromatographictechniques.

TroponinI(TnI)troponinT(TnT)andtroponinC(TnC)formthetroponincomplexofthinfilamentsofstriatedmuscle.TnIactsastheinhibitorysubunitbyblockingactin-myosininteractionsandtherebymediatingstriatedmusclerelaxation.TheTnIsubfamilyconsistsof3genes:TnI-skeletal-fast-twitch,TnI-skeletal-slow-twitch,andTnI-cardiac.TheTNNI3geneencodestheTnI-cardiacproteinandisexclusivelyexpressedincardiacmuscletissue.MutationsintheTNNI3genecausefamilialhypertrophiccardiomyopathytype7andfamilialrestrictivecardiomyopathy.

RecombinantHumanTnIproducedinE.coliisasingle,non-glycosylatedpolypeptidechaincontaining165aminoacidswithamolecularweightof24kDa.

Source:Escherichiacoli

Purity:Greaterthan98%asdeterminedbySDS-PAGEandRP-HPLC.

Accessionnumber:P19429

Althoughstableat4oCfor1week,productisbeststoredatorbelow-20oC.Additionofacarrierprotein(suchas0.1%HSAorBSA)isrecommendedforlong-termstorage.

Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.

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