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BioVision/AITRL, Human Recombinant/7113/

Description:

AITRL,amemberoftheTNFsuperfamily,isexpressedinendothelialcells,andsignalsthroughtheAITRreceptor.AITRLregulatesT-cellproliferationandsurvival,andeffectuatestheinteractionbetweenTlymphocytesandendothelialcells.TheAITRLgenecodesforatypeIItransmembraneproteincomprisedof177aminoacids,includinga28aminoacidcytoplasmicregion,a21aminoacidtransmembranedomainanda128aminoacidextracellulardomain.RecombinanthumansolubleAITRLisa14.4kDaprotein,containing127aminoacidresiduescorrespondingtotheextracellulardomainofAITRL.
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AlternateNameActivation-inducedTNFRmemberLigand,TNFSF18,GITRL,TL-6
GeneSymbolTNFSF18
GeneID8995
Accession#Q9UNG2
SourceE.coli.
AppearanceLyophilizedpowder
PhysicalFormDescriptionSterilefilteredthrougha0.2micronfilter.Lyophilizedfrom10mMTris,pH8.0.
MolecularWeight14.4kDa
PuritybySDS-PAGE≥98%
EndotoxinLevel<0.1=""ng/μg=""of=""protein=""><1eu>
BIOLOGicalActivityDeterminedbyitsABIlitytostimulateIL-8productionbyhumanPBMCusingaconcentrationrangeof1.0-10.0ng/ml.Note:ResultsmayvarywithPBMCdonors.
ReconstitutionInstructionsCentrifugethevialpriortoopening.Reconstituteinwatertoaconcentrationof0.1-1.0mg/ml.Donotvortex.Forextendedstorage,itisrecommendedtofurtherdiluteinabuffercontainingacarrierprotein(example0.1%BSA)andstoreinworkingaliq
AminoAcidSequenceMETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFIS
HandlingCentrifugethevialpriortoopening.
StorageConditions-20°C
ShippingConditionsGelPack
USAGEForResearchUseOnly!Nottobeusedinhumans