免疫检查点蛋白Immune Checkpoint Proteins

GeneralDescription

免疫检查点（ImmuneCheckpoint）通路包括共刺激蛋白（costimulatoryprotein）和抑制蛋白（inhibitoryprotein）。共刺激蛋白会传导信号促进对病原体的免疫反应。相反，抑制性蛋白则负向调节淋巴细胞的活性，以防止过度的炎症反应。肿瘤细胞可以通过劫持免疫检查点通路，从而逃避免疫系统的攻击。因此，研究者相信调控免疫检查点通路可使免疫系统重新激活，从而对抗肿瘤。值得一提的是，anti-CTLA4和anti-PD-1单克隆抗体药物已经在多种恶性肿瘤的临床实验中显示了不错的疗效，同时研究人员也在开发针对其他检查点蛋白的抗体药物。

ProductList

AComprehensiveCollectionofCheckpointProteins

Weprovideacomprehensivecollectionofimmunecheckpointproteins.WeofferFc-tagged,His-tagged,Strep-tagged,and/ortagfreeversionsoftheseproteins.Inadditiontohumanproteins,wealsooffermouse,rat,rabbit,rhesusmacaque,andcynomolgusproteinsforyourexperimentalanimalstudies.

HighQualityMaterials

Theconsistencyinpurityandbioactivityisessentialforrecombinantproteins.Allourproteinshavetogothroughstringentpurityandbioactivityassessmentinavarietyofassays.Commonstandardinclude: a)Puritygreaterthan90%bySDS-PAGEandSEC-HPLC b)BioactivityvalidatedinfunctionalELISA c)Endotoxinlessthan1EU/µgbytheLALmethod

Fig.1 ThepurityofHumanPD-L1(Cat# PD1-H5229)was>95%asdeterminedbySEC-HPLCand>98%asdeterminedbySDS-PAGE.

Fig.2 BioactivityofPD1(Cat# PD1-H5221)wasmeasuredinafunctionalELISAagainsthumanPDL1(Cat# PD1-H5258).

Biotin-labeled&Heavy-labeledProteinsAvailable

Biotinlabelingcanmakeyourassaydevelopmentmucheasier.Weofferavarietyofready-to-usebiotinylatedcheckpointproteins.Theseproteinsareproducedusingourin-housedevelopedlabelingtechniques,whichconfershighbioactivityandminimalbatch-to-batchvariation.

Inaddition,wealsoofferheavy-labeledimmunecheckpointproteins,whichcanbeusedinquantitativemassspectrometry.

InhibitorScreeningKitAvailable

WearenowofferingaPD1-PD-L1inhibitorscreeningassaykit(Cat# EP-101)forrapidandhighthroughputscreeningofcandidateinhibitoryantibodiesorsmallmoleculesofthePD1pathway

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4-1BB	4-1BBLigand	CD80	CD86	B7H4
BTLA	VISTA	CD27	CD70	CD28
CD40	CD40Ligand	CTLA-4	DNAM-1	GITR
GITRLigand	HVEM	ICOS	LAG-3	OX40
OX40Ligand	PD-1	PD-L1	PD-L2	CD47
TIGIT	TIM-3	2B4	B7-H2	CD155
SIRPalpha		B7-H3	Galectin-9

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免疫检查点蛋白Immune Checkpoint Proteins