Signosis/Rat PPAR gamma Regulated cDNA Plate Array/AP1161/1 Ea

Description:

Theperoxisome-proliferatoractivatedreceptorgamma(PPARgamma)isamemberofthenuclearreceptorsuperfamilyoftranscriptionfactors.PPARgammaisimportanttoavarietyofbiologicalprocesses,suchasadipocytedifferentiation,glucosehomeostasis,lipidtraffickingaswellasvascularfunctionandhypertension.PPARgammaexertsitseffectsbyregulatingtargetgenetranscriptioninaligand-dependentmanner.Uponactivation,thePPARgamma-RXRheterodimerbindstospecificDNAsequencesonthetargetgenepromoterandleadstotranscriptionalregulation.

ApplicableGrid:

ListofApplicableGenes

1

2

3

4

5

6

7

8

9

10

11

12

A

PKA(Prkaca)

NfkB(NfkB1)

CD36

PKA(Prkaca)

NfkB(NfkB1)

CD36

PKA(Prkaca)

NfkB(NfkB1)

CD36

PKA(Prkaca)

NfkB(NfkB1)

CD36

B

PKC(Prkcg)

NOS1

CD40

PKC(Prkcg)

NOS1

CD40

PKC(Prkcg)

NOS1

CD40

PKC(Prkcg)

NOS1

CD40

C

cAMP

NOS2

B-actin

cAMP

NOS2

B-actin

cAMP

NOS2

B-actin

cAMP

NOS2

B-actin

D

ERK(EphB1)

NOS3

Klotho

ERK(EphB1)

NOS3

Klotho

ERK(EphB1)

NOS3

Klotho

ERK(EphB1)

NOS3

Klotho

E

JNK(Mapk8)

PPARa

Nephrin(Nphs1)

JNK(Mapk8)

PPARa

Nephrin(Nphs1)

JNK(Mapk8)

PPARa

Nephrin(Nphs1)

JNK(Mapk8)

PPARa

Nephrin(Nphs1)

F

Raf-1

PPARß/d

Rho

Raf-1

PPARß/d

Rho

Raf-1

PPARß/d

Rho

Raf-1

PPARß/d

Rho

G

GRK-2(Adrbk1)

PPARgamma

GAPDH

GRK-2(Adrbk1)

PPARgamma

GAPDH

GRK-2(Adrbk1)

PPARgamma

GAPDH

GRK-2(Adrbk1)

PPARr

GAPDH

H

GRK-4

NFAT(Nfat5)

Blank

GRK-4

NFAT(Nfat5)

Blank

GRK-4

NFAT(Nfat5)

Blank

GRK-4

NFAT(Nfat5)

Blank