Description | Dapagliflozinisanewpharmacologicaltherapyfortype2diabetes,andinhibitssodium/glucosecotransporter2(SGLT2),whichresultsinexcretionofglucoseintotheurine. |
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InVitro | DapagliflozinpretreatmentofhypoxicHK2cellssignificantlyimprovesthecellviABIlityinadose-dependentmanner.DapagliflozindecreasesBaxexpression,theBax/Bcl2ratio,andPARPexpressioninhypoxicHK2cells[2]. |
InVivo | At11mMglucose,dapagliflozinraisesglucagonreleasefrom18%to32%ofcontrol,whiletheeffectofdapagliflozinadditionisminorat1mMglucose.Attheintermediateglucoseconcentrationof6mM,glucagonsecretionisestimatedtobe24%and30%ofcontrolintheabsenceorpresenceofdapagliflozin,respectively[1].DapagliflozinpretreatmentsignificantlyreducesthenumberofTUNEL-positivecellsinIR-injuredkidneys.DapagliflozinpretreatmentsignificantlyelevatestheHIF1expressioninIR-injuredrenaltubularcellsfrommice[2].Dapagliflozin(10mg/kg,o.p.)causesamarkedincreaseinurinaryglucoseinSGLT2i-mice.DapagliflozinacutelysuppressesBATThermogenesisbyreducingsympatheticnerveactivity.Dapagliflozinenhanceshepaticgluconeogenesisandglycogenolysis[3]. |
ClinicalTrial | ViewMoreCollapse |
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CellAssay [2] | Toperformthecellsurvivalassay,cellsarecollectedafter24hincubationwithvehicleordapagliflozinpretreatmentin30-minischemiaandsurvivingcellsarecountedwithTrypanbluestaining.Thepercentagesurvivalisdeterminedbyquantizationoftherelativeviablenumberoftreatedcellsdividedbytheviablenumberofuntreatedcells.MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly. AnimalAdmiNISTration | [1] 10-week-oldmaleC57BL/6miceweighing30-33geacharedividedintofivegroups:vehicle(Vh)-treatedsham(n=5),dapagliflozin-treatedsham(n=5),Vh-treatedIR(n=7),dapagliflozin-treatedIR(n=7),andalbendazoleanddapagliflozintreatedIR(n=7).Dapagliflozinisadministratedviaoralgavageatadoseof10mg/kg/dayfor2days,starting24hbeforesurgery.Albendazoleisinjectedsubcutaneously1hbeforeIRsurgery.MCEhasnotindependentlyconfirmedtheaccuracyofthesemethods.Theyareforreferenceonly. References |
Purity:99.89%
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