MedKoo Biosciences/PF-4708671/406432/200mg

Synonym:PF4708671;PF-4708671;PF4708671.

IUPAC/ChemicalName:2-((4-(5-ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole

SMILESCode:FC(C1=CC=C2NC(CN3CCN(C4=NC=NC=C4CC)CC3)=NC2=C1)(F)F

TechnicalData

AdditionalInformation

 S6K1(p70ribosomalS6kinase1)isactivatedbyinsulinandgrowthfactorsviathePI3K(phosphoinositide3-kinase)andmTOR(mammaliantargetofrapamycin)signallingpathways.S6K1regulatesnumerousprocesses,suchasproteinsynthesis,growth,proliferationandlongevity,anditsinhibitionhasbeenproposedasastrategyforthetreatmentofcancerandinsulinresistance. 
 
 
 

References

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5:ChoiHN,JinHO,KimJH,HongSE,KimHA,KimEK,LeeJK,ParkIC,NohWC.InhibitionofS6K1enhancesglucosedeprivation-inducedcelldeathviadownregulationofanti-apoptoticproteinsinMCF-7breastcancercells.BiochemBiophysResCommun.2013Mar1;432(1):123-8.doi:10.1016/j.bbrc.2013.01.074.Epub2013Jan29.PubMedPMID:23376066.

6:DiR,WuX,ChangZ,ZhaoX,FengQ,LuS,LuanQ,HemmingsBA,LiX,YangZ.S6KinhibitionrenderscardiacprotectionagainstmyocardialinfarctionthroughPDK1phosphorylationofAkt.BiochemJ.2012Jan1;441(1):199-207.doi:10.1042/BJ20110033.PubMedPMID:21906027.

7:RosnerM,SchipanyK,HengstschlägerM.p70S6K1nuclearlocalizationdependsonitsmTOR-mediatedphosphorylationatT389,butnotonitskinaseactivitytowardsS6.AminoAcids.2012Jun;42(6):2251-6.doi:10.1007/s00726-011-0965-4.Epub2011Jun28.PubMedPMID:21710263.

8:BilangesB,VanhaesebroeckB.Anewtooltodissectthefunctionofp70S6kinase.BiochemJ.2010Oct15;431(2):e1-3.doi:10.1042/BJ20101445.PubMedPMID:20874709.

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