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MedKoo Biosciences/CM-352/510334/100mg

CM-352isapotentMMPinhibitor,whichinhibitedfibrinolysisinhumanwholebloodfunctionalassaysandwasmoreeffectivethanthecurrentstandardofcare,tranexamicacid,inthetail-bleedingmodelusinga30,000timeslowerdose.Moreover,CM-352reducedbloodlossduringliverhepatectomy.CM352displayedoptimalpharmacokineticandsafetyprofileswithnoevidenceofthrombosisorcoagulationimpairment.Thisnovelmechanismofaction,targetingMMP,definesanewclassofantihemorrhagicagentswithoutinterferingwithnormalhemostaticfunction.FurThermore,CM-352representsapre-clinicalcandidatefortheacutetreatmentofbleeding.

MedKooCat#:510334
Name:CM-352
CAS#:1542205-83-3
ChemicalFormula:C24H29N3O6S
ExactMass:487.17771
MolecularWeight:487.57
ElementalAnalysis:C,59.12;H,6.00;N,8.62;O,19.69;S,6.58


Synonym:CM352;CM352;CM-352.

IUPAC/ChemicalName:(R)-N-hydroxy-2-((4-(4-(methylcarbamoyl)phenoxy)phenyl)sulfonyl)-8-azaspiro[4.5]decane-2-carboxamide

InChiKey:ZUZGJCNWNOCKEB-XMMPIXPASA-N

InChiCode:InChI=1S/C24H29N3O6S/c1-25-21(28)17-2-4-18(5-3-17)33-19-6-8-20(9-7-19)34(31,32)24(22(29)27-30)11-10-23(16-24)12-14-26-15-13-23/h2-9,26,30H,10-16H2,1H3,(H,25,28)(H,27,29)/t24-/m1/s1

SMILESCode:O=C(NC)C1=CC=C(OC2=CC=C(S(=O)([C@]3(C(NO)=O)CCC4(CCNCC4)C3)=O)C=C2)C=C1.


TechnicalData

Appearance:
Solidpowder

Purity:
>98%(orrefertotheCertificateofAnalysis)

ShippingCondition:
Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:
Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:
SolubleinDMSO,notinwater

ShelfLife:
>2yearsifstoredproperly

DrugFormulation:
ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:
0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:
293490


AdditionalInformation

  
 
 
 


References

1:OrbeJ,RodriguezJA,Sanchez-AriasJA,SalicioA,BelzunceM,UgarteA,ChangHC,RabalO,OyarzabalJ,ParamoJA.Discoveryandsafetyprofilingofapotentpre-clinicalcandidate,(4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methyl-benzamide)(CM-352),forthepreventionandtreatmentofhemorrhage.JMed Chem.2015Feb16.[Epubaheadofprint]PubMedPMID:25686022.

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