Deprecated: Required parameter $cat_id follows optional parameter $type in /www/wwwroot/ebimall.com/systems/hong.php on line 2088

Deprecated: Required parameter $where follows optional parameter $tree_id in /www/wwwroot/ebimall.com/systems/hlb.php on line 3505
MedKoo Biosciences/Go6983/406136/25mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
您好,欢迎您进入188进口试剂采购网网站! 服务热线:4000-520-616
蚂蚁淘商城 | 现货促销 | 科研狗 | 生物在线

MedKoo Biosciences/Go6983/406136/25mg

GO6983isapotentproteinkinaseC(PKC)inhibitor.GO6893displayscardioprotectiveproperties;reducespolymorphonuclearleukocyteadherenceandinfiltrationfollowingmyocardialischemia/reperfusioninjury.

MedKooCat#:406136
Name:Go6983
CAS#:133053-19-7
ChemicalFormula:C26H26N4O3
ExactMass:442.20049
MolecularWeight:442.51
ElementalAnalysis:C,70.57;H,5.92;N,12.66;O,10.85


Synonym:Go6983Go-6983;Go6983;GO6983;GO6983;GO-6983

IUPAC/ChemicalName:3-(1-(3-(dimethylamino)propyl)-5-methoxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

InChiKey:LLJJDLHGZUOMQP-UHFFFAOYSA-N

InChiCode:InChI=1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)

SMILESCode:O=C(C(C1=CN(CCCN(C)C)C2=C1C=C(OC)C=C2)=C3C4=CNC5=C4C=CC=C5)NC3=O


TechnicalData

Appearance:
Solidpowder

Purity:
>98%

ShippingCondition:
Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:
Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:
SolubleinDMSO,notinwater

ShelfLife:
>5yearsifstoredproperly

DrugFormulation:
ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:
0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:
293490


AdditionalInformation

  
 
 
 


References

1:DaiB,ZhangJ,LiuM,LuJ,ZhangY,XuY,MiaoJ,YinY.TheroleofCa(2+)mediatedsignalingpathwaysontheeffectoftaurineagainstStreptococcusuberisinfection.VetMicrobiol.2016Aug30;192:26-33.doi:10.1016/j.vetmic.2016.06.008.PubMedPMID:27527761.

2:OlianasMC,DedoniS,OnaliP.Protectionfrominterferon-β-inducedneuronalapoptosisthroughstimulationofmuscarinicacetylcholinereceptorscoupledtoERK1/2activation.BrJPharmacol.2016Oct;173(19):2910-28.doi:10.1111/bph.13570.PubMedPMID:27474091.

3:HuSY,TongGJ,MengY,HaoS,LiW,XuFL,HeYH,ChenJT,YangDH.[ParathyroidhormoneinhibitstheapoptosisofosteoblastMC-3T3E1cellsthroughanon-PLC-dependentproteinkinaseCpathway].NanFangYiKeDaXueXueBao.2016Jun;36(6):785-9.Chinese.PubMedPMID:27320879.

4:MengZ,BischofJ,IanesC,Henne-BrunsD,XuP,KnippschildU.CK1δkinaseactivityismodulatedbyproteinkinaseCα(PKCα)-mediatedsite-specificphosphorylation.AminoAcids.2016May;48(5):1185-97.doi:10.1007/s00726-015-2154-3.PubMedPMID:26803658.

5:JianY,ChenC,LiB,TianX.DelocalizedClaudin-1promotesmetastasisofhumanosteosarcomacells.BiochemBiophysResCommun.2015Oct23;466(3):356-61.doi:10.1016/j.bbrc.2015.09.028.PubMedPMID:26361141.

6:ThengchaisriN,HeinTW,RenY,KuoL.Endothelin-1impairscoronaryarteriolardilation:Roleofp38kinase-mediatedsuperoxideproductionfromNADPHoxidase.JMolCellCardiol.2015Sep;86:75-84.doi:10.1016/j.yjmcc.2015.07.014.PubMedPMID:26211713;PubMedCentralPMCID:PMC4558216.

7:WeiX,ZhangB,ChengL,ChiM,DengL,PanH,YaoX,WangG.Hydrogensulfideinducesneuroprotectionagainstexperimentalstrokeinratsbydown-regulationofAQP4viaactivatingPKC.BrainRes.2015Oct5;1622:292-9.doi:10.1016/j.brainres.2015.07.001.PubMedPMID:26168888.

8:AlcantaraC,MazaPK,BarrosBC,SuzukiE.RoleofproteinkinaseCincytokinesecretionbylungepithelialcellsduringinfectionwithParacoccidioidesbrasiliensis.PathogDis.2015Oct;73(7).pii:ftv045.doi:10.1093/femspd/ftv045.PubMedPMID:26152710;PubMedCentralPMCID:PMC4626587.

9:XuH,CzerwinskiP,XiaN,FörstermannU,LiH.DownregulationofBDNFExpressionbyPKCandbyTNF-αinHumanEndothelialCells.Pharmacology.2015;96(1-2):1-10.doi:10.1159/000430823.PubMedPMID:26021525.

10:HaoS,MengY,LiW,HuSY,YangDH.[ActivationofphospholipaseC-independentproteinkinaseCsignalingpathwayofparathyroidhormoneenhancesCITED1expressioninmouseosteoblasts].NanFangYiKeDaXueXueBao.2015Apr;35(4):486-91.Chinese.PubMedPMID:25907930.

11:HouJ,WangZ,XuH,YangL,YuX,YangZ,DengY,MengJ,FengY,GuoX,YangG.Stanniocalicin2suppressesbreastcancercellmigrationandinvasionviathePKC/claudin-1-mediatedsignaling.PLoSOne.2015Apr1;10(4):e0122179.doi:10.1371/journal.pone.0122179.PubMedPMID:25830567;PubMedCentralPMCID:PMC4382185.

12:IkariA,FujiiN,HahakabeS,HayashiH,YamaguchiM,YamazakiY,EndoS,MatsunagaT,SugataniJ.Hyperosmolarity-InducedDown-RegulationofClaudin-2MediatedbyDecreaseinPKCβ-DependentGATA-2inMDCKCells.JCellPhysiol.2015Nov;230(11):2776-87.doi:10.1002/jcp.25004.PubMedPMID:25825272.

13:HoriT,BarnorJ,HuuTN,MorinagaO,HamanoA,NdzinuJ,FrimpongA,Minta-AsareK,Amoa-BosompemM,BrandfulJ,OdoomJ,BonneyJ,TuffourI,OwusuBA,OfosuheneM,AtchogloP,SakyiamahM,AdegleR,Appiah-OpongR,AmpofoW,KoramK,NyarkoA,OkineL,EdohD,AppiahA,UtoT,YoshinakaY,UotaS,ShoyamaY,YamaokaS.ProcyanidintrimerC1derivedfromTheobromacacaoreactivateslatenthumanimmunodeficiencyvirustype1provirus.BiochemBiophysResCommun.2015Apr3;459(2):288-93.doi:10.1016/j.bbrc.2015.02.102.Erratumin:BiochemBiophysResCommun.2015Jun12;461(4):702.PubMedPMID:25727021.

14:HsuH,BaldwinCL,TelferJC.TheendocytosisandsignalingoftheγδTcellcoreceptorWC1areregulatedbyadileucinemotif.JImmunol.2015Mar1;194(5):2399-406.doi:10.4049/jimmunol.1402020.PubMedPMID:25632004.

15:BianJM,WuN,SuRB,LiJ.Phosphatidylethanolamine-bindingproteinisnotinvolvedinµ-opioidreceptor-mediatedregulationofextracellularsignal-regulatedkinase.MolMedRep.2015May;11(5):3368-74.doi:10.3892/mmr.2015.3161.PubMedPMID:25573435;PubMedCentralPMCID:PMC4368089.

16:KuanCS,YeeYH,SeeTooWC,FewLL.EtsandGATAtranscriptionfactorsplayacriticalroleinPMA-mediatedrepressionoftheckβpromoterviatheproteinkinaseCsignalingpathway.PLoSOne.2014Dec9;9(12):e113485.doi:10.1371/journal.pone.0113485.PubMedPMID:25490397;PubMedCentralPMCID:PMC4260826.

17:KawataJ,AokiM,IshimaruY,OnoT,SagaraK,NaraharaS,MatsmotoT,HiroseE,YamaguchiY.Mechanismoftissuefactorproductionbymonocytesstimulatedwithneutrophilelastase.BloodCellsMolDis.2015Feb;54(2):206-9.doi:10.1016/j.bcmd.2014.10.005.PubMedPMID:25465717.

18:RavehA,SchultzPJ,AschermannL,CarpenterC,Tamayo-CastilloG,CaoS,ClardyJ,NeubigRR,ShermanDH,SjögrenB.IdentificationofproteinkinaseCactivationasanovelmechanismforRGS2proteinupregulationthroughphenotypicscreeningofnaturalproductextracts.MolPharmacol.2014Oct;86(4):406-16.doi:10.1124/mol.114.092403.PubMedPMID:25086086.

19:LinZ,FengR,LiJ,MengY,YuanL,FuZ,GuoJ,BringhurstFR,YangD.NucleartranslocationofCBP/p300-interactingproteinCITED1inducedbyparathyroidhormonerequiresserinephosphorylationatposition79inits63-84domain.CellSignal.2014Nov;26(11):2436-45.doi:10.1016/j.cellsig.2014.06.015.PubMedPMID:25049079.

20:YanH,MaYL,GuiYZ,WangSM,WangXB,GaoF,WangYP.MG132,aproteasomeinhibitor,enhancesLDLuptakeinHepG2cellsinvitrobyregulatingLDLRandPCSK9expression.ActaPharmacolSin.2014Aug;35(8):994-1004.doi:10.1038/aps.2014.52.PubMedPMID:25042549;PubMedCentralPMCID:PMC4125719.


新闻动态
行业前沿
技术文章
最新产品

188进口试剂采购网 www.188bio.cn -中国试剂网,试剂网,化学试剂网,国药试剂,抗体公司,试剂公司,试剂盒公司,苏州试剂公司,北京化学试剂公司,天津化学试剂,试剂商城,试剂代理,流式抗体 细胞库查询 sitemap