MedKoo Biosciences/CHIR98014/510328/1g

CHIR98014isareversible,cell-permeableinhibitorofGSK3αandGSK3β(IC50=0.65and0.58nM,respectively).Itisinactiveagainstaseriesofotherserine/threonineortyrosinekinases.ThroughitseffectsonGSK3,CHIR98014stimulatesglycogensynthaseincells(EC50=106nM),potentiatesinsulin-dependentglucosetransportinisolatedmusclestrips,andimprovesglucosedisposalindiabeticanimals.CHIR98014alsoreducestauphosphorylationinratbrainsandsupportsWntsignalingduringosteogenesis.

MedKooCat#:510328
Name:CHIR98014
CAS#:556813-39-9
ChemicalFormula:C20H17Cl2N9O2
ExactMass:485.08823
MolecularWeight:486.31
ElementalAnalysis:C,49.39;H,3.52;Cl,14.58;N,25.92;O,6.58

Synonym:CHIR98014;CHIR-98014;CHIR98014.

IUPAC/ChemicalName:N2-(2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine

InChiKey:NDFXSHIIGXVOKT-UHFFFAOYSA-N

InChiCode:InChI=1S/C20H17Cl2N9O2/c21-11-1-2-12(14(22)9-11)17-13(19-25-6-7-26-19)10-28-20(30-17)27-8-5-24-16-4-3-15(31(32)33)18(23)29-16/h1-4,6-7,9-10H,5,8H2,(H,25,26)(H3,23,24,29)(H,27,28,30)

SMILESCode:NC1=NC(NCCNC2=NC=C(C3=NC=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2)=CC=C1[N+]([O-])=O

TechnicalData

Appearance:

Solidpowder

Purity:

>98%(orrefertotheCertificateofAnalysis)

CertificateofAnalysis:

ViewCoA:currentbatch,Lot#BBC50628

QCData:

ViewQCdata:currentbatch,Lot#BBC50628

SafetyDataSheet(MSDS):

ViewMaterialSafetyDataSheet(MSDS)

ShippingCondition:

Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:

Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:

SolubleinDMSO,notinwater

ShelfLife:

>2yearsifstoredproperly

DrugFormulation:

ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:

0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:

293490

AdditionalInformation

References

1:NaujokO,LentesJ,DiekmannU,DavenportC,LenzenS.CytotoxicityandactivationoftheWnt/beta-cateninpathwayinmouseembryonicstemcellstreatedwithfourGSK3inhibitors.BMCResNotes.2014Apr29;7:273.doi:10.1186/1756-0500-7-273.PubMedPMID:24779365;PubMedCentralPMCID:PMC4008422.

2:RingDB,JohnsonKW,HenriksenEJ,NussJM,GoffD,KinnickTR,MaST,ReederJW,SamuelsI,SlabiakT,WagmanAS,HammondME,HarrisonSD.Selectiveglycogensynthasekinase3inhibitorspotentiateinsulinactivationofglucosetransportandutilizationinvitroandinvivo.Diabetes.2003Mar;52(3):588-95.PubMedPMID:12606497.

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MedKoo Biosciences/CHIR98014/510328/1g

TechnicalData

AdditionalInformation

References