MedKooCat#:205531
Name:Binimetinib(MEK-162)
CAS#:606143-89-9
ChemicalFormula:C17H15BrF2N4O3
ExactMass:440.02956
MolecularWeight:441.22681
ElementalAnalysis:C,46.28;H,3.43;Br,18.11;F,8.61;N,12.70;O,10.88
Synonym:MEK162;MEK-162;MEK162;ARRY162;ARRY-162;ARRY162;ARRY438162,Binimetinib
IUPAC/ChemicalName:5-((4-bromo-2-fluorophenyl)amino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide.
InChiKey:ACWZRVQXLIRSDF-UHFFFAOYSA-N
InChiCode:InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
SMILESCode:O=C(C1=C(NC2=CC=C(Br)C=C2F)C(F)=C3N=CN(C)C3=C1)NOCCO
1:HamidiH,LuM,ChauK,AndersonL,FejzoM,GintherC,LinnartzR,ZubelA,SlamonDJ,FinnRS.KRASmutationalsubtypeandcopynumberpredictinvitroresponseofhumanpancreaticcancercelllinestoMEKinhibition.BrJCancer.2014Aug28.doi:10.1038/bjc.2014.475.[Epubaheadofprint]PubMedPMID:25167228.
2:RebeccaVW,AliceaGM,ParaisoKH,LawrenceH,GibneyGT,SmalleyKS.VerticalinhibitionoftheMAPKpathwayenhancestherapeuticresponsesinNRAS-mutantmelanoma.PigmentCellMelanomaRes.2014Aug11.doi:10.1111/pcmr.12303.[Epubaheadofprint]PubMedPMID:25130256.
3:Urner-BlochU,UrnerM,StiegerP,GallikerN,WintertonN,ZubelA,Moutouh-deParsevalL,DummerR,GoldingerSM.TransientMEKinhibitor-associatedretinopathyinmetastaticmelanoma.AnnOncol.2014Jul;25(7):1437-41.doi:10.1093/annonc/mdu169.Epub2014May26.PubMedPMID:24864047.
4:Küsters-VandeveldeHV,WillemsenAE,GroenenPJ,KüstersB,LammensM,WesselingP,DjafarihamedaniM,RijntjesJ,DelyeH,WillemsenMA,vanHerpenCM,BlokxWA.ExperimentaltreatmentofNRAS-mutatedneurocutaneousmelanocytosiswithMEK162,aMEK-inhibitor.ActaNeuropatholCommun.2014Apr8;2(1):41.doi:10.1186/2051-5960-2-41.PubMedPMID:24713450;PubMedCentralPMCID:PMC4023633.
5:ThumarJ,ShahbazianD,AzizSA,JilaveanuLB,KlugerHM.MEKtargetinginN-RASmutatedmetastaticmelanoma.MolCancer.2014Mar4;13:45.doi:10.1186/1476-4598-13-45.PubMedPMID:24588908;PubMedCentralPMCID:PMC3945937.
6:GritsmanK,YuzugulluH,VonT,YanH,ClaytonL,FritschC,MairaSM,HollingworthG,ChoiC,KhandanT,PaktinatM,OkabeRO,RobertsTM,ZhaoJJ.HematopoiesisandRAS-drivenmyeloidleukemiadifferentiallyrequirePI3Kisoformp110α.JClinInvest.2014Apr1;124(4):1794-809.doi:10.1172/JCI69927.Epub2014Feb24.PubMedPMID:24569456;PubMedCentralPMCID:PMC3973083.
7:MillerCR,OliverKE,FarleyJH.MEK1/2inhibitorsinthetreatmentofgynecologicmalignancies.GynecolOncol.2014Apr;133(1):128-37.doi:10.1016/j.ygyno.2014.01.008.Epub2014Jan14.Review.PubMedPMID:24434059.
8:ChenX,WuQ,TanL,PorterD,JagerMJ,EmeryC,BastianBC.CombinedPKCandMEKinhibitioninuvealmelanomawithGNAQandGNA11mutations.Oncogene.2013Oct21.doi:10.1038/onc.2013.418.[Epubaheadofprint]PubMedPMID:24141786.
9:DavarD,TarhiniAA,KirkwoodJM.Adjuvantimmunotherapyofmelanomaanddevelopmentofnewapproachesusingtheneoadjuvantapproach.ClinDermatol.2013May-Jun;31(3):237-50.doi:10.1016/j.clindermatol.2012.08.012.Review.Erratumin:ClinDermatol.2013Jul-Aug;31(4):501.PubMedPMID:23608443;PubMedCentralPMCID:PMC3654101.
10:AkinleyeA,FurqanM,MukhiN,RavellaP,LiuD.MEKandtheinhibitors:frombenchtobedside.JHematolOncol.2013Apr12;6:27.doi:10.1186/1756-8722-6-27.Review.PubMedPMID:23587417;PubMedCentralPMCID:PMC3626705.
matriks/Shikari® (S-ATP) Anti-Pembrolizumab ELISA w/confirmation/PEM-QNS-KEY
intactgenomics/Methionine Auxotrophic LBA4404 | ig® | Intact Genomics/15x50μl/1076-15
goprolytix/Proteolytic Activation of Prothrombin/1 mg, 200 µg/BCT-DFP
novateinbio/Dynorphin A ( 13-17 ) Porcine Peptide/5mg/PE-54024_5mg
matriks/Shikari® (Q-ETA) Etanercept ELISA/ETA-FD-ENB
intactgenomics/Agrobacterium ElectroComponent Combo Pack | Intact Genomics/12x50µl/1290-24
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Jackson/Peroxidase AffiniPure Goat Anti-Rabbit IgG (H+L)/2.0 ml/111-035-003
Qubit™ dsDNA BR Assay Kit Q32853现货
Invitrogen Q32855 Qubit™ RNA HS Assay Kit现货促销
LUCK-1G,D-Luciferin, Potassium Salt 钾盐现货
GoldBio/D-Luciferin, Sodium Salt (Proven and Published)/LUCNA-1G/1 g