MedKooCat#:200820
Name:CP-724714
CAS#:383432-38-0
ChemicalFormula:C27H27N5O3
ExactMass:469.21139
MolecularWeight:469.53
ElementalAnalysis:C,69.07;H,5.80;N,14.92;O,10.22
Synonym:CP724714;CP724714;CP-724714.
IUPAC/ChemicalName:(E)-2-methoxy-N-(3-(4-(3-methyl-4-(6-methylpyridin-3-yloxy)phenylamino)quinazolin-6-yl)allyl)acetamide.
InChiKey:LLVZBTWPGQVVLW-SNAWJCMRSA-N
InChiCode:InChI=1S/C27H27N5O3/c1-18-13-21(8-11-25(18)35-22-9-6-19(2)29-15-22)32-27-23-14-20(7-10-24(23)30-17-31-27)5-4-12-28-26(33)16-34-3/h4-11,13-15,17H,12,16H2,1-3H3,(H,28,33)(H,30,31,32)/b5-4+
SMILESCode:O=C(NC/C=C/C1=CC2=C(NC3=CC=C(OC4=CC=C(C)N=C4)C(C)=C3)N=CN=C2C=C1)COC
1:FengB,XuJJ,BiYA,MirelesR,DavidsonR,DuignanDB,CampbellS,KostrubskyVE,DunnMC,SmithAR,WangHF.RoleofhepatictransportersinthedispositionandhepatotoxicityofaHER2tyrosinekinaseinhibitorCP-724,714.ToxicolSci.2009Apr;108(2):492-500.doi:10.1093/toxsci/kfp033.Epub2009Feb17.PubMedPMID:19223659.
2:JaniJP,FinnRS,CampbellM,ColemanKG,ConnellRD,CurrierN,EmersonEO,FloydE,HarrimanS,KathJC,MorrisJ,MoyerJD,PustilnikLR,RafidiK,RalstonS,RossiAM,SteynSJ,WagnerL,WinterSM,BhattacharyaSK.DiscoveryandpharmacologiccharacterizationofCP-724,714,aselectiveErbB2tyrosinekinaseinhibitor.CancerRes.2007Oct15;67(20):9887-93.PubMedPMID:17942920.
3:GuoF,LetrentSP,MunsterPN,BrittenCD,GelmonK,TolcherAW,SharmaA.PharmacokineticsofaHER2tyrosinekinaseinhibitorCP-724,714inpatientswithadvancedmalignantHER2positivesolidtumors:correlationswithclinicalcharacteristicsandsafety.CancerChemotherPharmacol.2008Jun;62(1):97-109.Epub2007Sep6.PubMedPMID:17805538.
4:MunsterPN,BrittenCD,MitaM,GelmonK,MintonSE,MoulderS,SlamonDJ,GuoF,LetrentSP,DenisL,TolcherAW.Firststudyofthesafety,tolerABIlity,andpharmacokineticsofCP-724,714inpatientswithadvancedmalignantsolidHER2-expressingtumors.ClinCancerRes.2007Feb15;13(4):1238-45.PubMedPMID:17317835.
5:GuoF,LetrentSP,SharmaA.PopulationpharmacokineticsofaHER2tyrosinekinaseinhibitorCP-724,714inpatientswithadvancedmalignantHER2positivesolidtumors.CancerChemotherPharmacol.2007Nov;60(6):799-809.Epub2007Feb7.PubMedPMID:17285315.
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