产品资料

MedKoo Biosciences/Indoximod/206160/200mg

Indoximod,alsoknownasNLG8189andD-1MT,isamethylatedtryptophanwithanti-immunosuppressiveactivity.1-methyl-d-tryptophaninhibitstheenzymeindoleamine2,3-dioxygenase(IDO),whichdegradestheessentialaminoacidtryptophan,andmayincreaseormaintaintryptophanlevelsimportanttoTcellfunction.TryptophandepletionisassociatedwithimmunosuppressioninvolvingTcellarrestandanergy.

MedKooCat#:206160
Name:Indoximod
CAS#:110117-83-4
ChemicalFormula:C12H14N2O2
ExactMass:218.10553
MolecularWeight:218.25
ElementalAnalysis:C,66.04;H,6.47;N,12.84;O,14.66

Synonym:Indoximod;NLG8189;NLG8189;NLG-8189;D1MT;1methylDtryptophan.

IUPAC/ChemicalName:(R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoicacid

InChiKey:ZADWXFSZEAPBJS-SNVBAGLBSA-N

InChiCode:InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1

SMILESCode:N[C@H](CC1=CN(C)C2=CC=CC=C12)C(O)=O

TechnicalData

Appearance:

Solidpowder

Purity:

>98%(orrefertotheCertificateofAnalysis)

CertificateofAnalysis:

ViewCoA:currentbatch,Lot#T7K09C05

QCData:

ViewQCdata:currentbatch,Lot#T7K09C05

SafetyDataSheet(MSDS):

ViewMaterialSafetyDataSheet(MSDS)

ShippingCondition:

Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:

Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:

SolubleinDMSO,notinwater

ShelfLife:

>2yearsifstoredproperly

DrugFormulation:

ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:

0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:

293490

AdditionalInformation

References

1:YimHS,ChoiKM,KimB,JungID,ParkYM,KangYK,LeeMG.Effectof1-methyl-D-tryptophanandadoptivetransferofdendriticcellsonpolymicrobialsepsisinducedbycecalcontentinjection.MicrobiolImmunol.2013Sep;57(9):633-9.doi:10.1111/1348-0421.12081.PubMedPMID:23841524.

2:OpitzCA,LitzenburgerUM,OpitzU,SahmF,OchsK,LutzC,WickW,PlattenM.Theindoleamine-2,3-dioxygenase(IDO)inhibitor1-methyl-D-tryptophanupregulatesIDO1inhumancancercells.PLoSOne.2011;6(5):e19823.doi:10.1371/journal.pone.0019823.Epub2011May20.PubMedPMID:21625531;PubMedCentralPMCID:PMC3098827.

3:Vasil'evaED,NikolinVP,PopovaNA,LushnikovaEL,KaledinVI.Inhibitorofindoleamine-2,3-dioxygenase1-methyl-D-tryptophancanstimulatethegrowthofimmunogenictumors.BullExpBiolMed.2010Oct;149(5):625-7.PubMedPMID:21165403.

4:JiaL,SchweikartK,TomaszewskiJ,PageJG,NokerPE,BuhrowSA,ReidJM,AmesMM,MunnDH.Toxicologyandpharmacokineticsof1-methyl-d-tryptophan:absenceoftoxicityduetosaturatingabsorption.FoodChemToxicol.2008Jan;46(1):203-11.Epub2007Aug10.PubMedPMID:17868966;PubMedCentralPMCID:PMC2744343.

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MedKoo Biosciences/Indoximod/206160/200mg

TechnicalData

AdditionalInformation

References