MedKoo Biosciences/TAK063/510331/25mg

TAK-063,alsoknownasBalipodect.,isahighlypotent,selective,andorallyactivephosphodiesterase10A(PDE10A)inhibitor.TAK-063iscurrentlybeingevaluatedinclinicaltrialsforthetreatmentofschizophrenia.Phosphodiesterase10A(PDE10A)isacAMP/cGMPphosphodiesterasehighlyexpressedinmediumspinyneurons(MSNs)inthestriatum.TAK-063representsapromisingdrugforthetreatmentofschizophreniawithpotentialforsuperiorsafetyandtolerabilityprofiles.

MedKooCat#:510331
Name:TAK-063
CAS#:1238697-26-1
ChemicalFormula:C23H17FN6O2
ExactMass:428.1397
MolecularWeight:428.42
ElementalAnalysis:C,64.48;H,4.00;F,4.43;N,19.62;O,7.47

Synonym:TAK063,TAK063,TAK-063,Balipodect

IUPAC/ChemicalName:1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

InChiKey:KVHRYLNQDWXAGI-UHFFFAOYSA-N

InChiCode:InChI=1S/C23H17FN6O2/c1-32-21-15-29(19-9-8-17(14-18(19)24)28-13-5-11-25-28)27-22(23(21)31)20-10-12-26-30(20)16-6-3-2-4-7-16/h2-15H,1H3

SMILESCode:O=C1C(C2=CC=NN2C3=CC=CC=C3)=NN(C4=CC=C(N5N=CC=C5)C=C4F)C=C1OC

TechnicalData

Appearance:

Whitetooff-whitesolidpowder

Purity:

>98%(orrefertotheCertificateofAnalysis)

CertificateofAnalysis:

ViewCoA:currentbatch,Lot#BBC60411

QCData:

ViewQCdata:currentbatch,Lot#BBC60411

SafetyDataSheet(MSDS):

ViewMaterialSafetyDataSheet(MSDS)

ShippingCondition:

Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:

Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:

SolubleinDMSO,notinwater

ShelfLife:

>2yearsifstoredproperly

DrugFormulation:

ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:

0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:

293490

References

1:SuzukiK,HaradaA,ShiraishiE,KimuraH.InVivoPharmacologicalCharacterizationofTAK-063,aPotentandSelectivePhosphodiesterase10AInhibitorwithAntipsychotic-LikeActivityinRodents.JPharmacolExpTher.2015Mar;352(3):471-9.doi:10.1124/jpet.114.218552.Epub2014Dec18.PubMedPMID:25525190.

2:KunitomoJ,YoshikawaM,FushimiM,KawadaA,QuinnJF,OkiH,KokuboH,KondoM,NakashimaK,KamiguchiN,SuzukiK,KimuraH,TaniguchiT.Discoveryof1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one(TAK-063),ahighlypotent,selective,andorallyactivephosphodiesterase10A(PDE10A)inhibitor.JMedChem.2014Nov26;57(22):9627-43.doi:10.1021/jm5013648.Epub2014Nov10.PubMedPMID:25384088.

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MedKoo Biosciences/TAK063/510331/25mg

TechnicalData

References