MedKoo Biosciences/RXDX105 (CEP32496)/205903/5mg

Agerafenib,alsoknownasRXDX-105,CEP-32496andAC013773,isanorallyavailablev-rafmurinesarcomaviraloncogenehomologB1(B-raf)serine/threonineproteinkinaseinhibitorwithpotentialantineoplasticactivity.CEP-32496specificallyandselectivelyinhibitstheactivityofthemutatedform(V600E)ofB-rafkinase.ThisinhibitstheactivationoftheRAF/mitogen-activatedproteinkinasekinase(MEK)/extracellularsignal-relatedkinase(ERK)signalingpathwayandmayresultinadecreaseintheproliferationoftumorcellsexpressingthemutatedB-rafgene.

MedKooCat#:205903
Name:RXDX-105(CEP-32496)
CAS#:1188910-76-0(freebase)
ChemicalFormula:C24H22F3N5O5
ExactMass:517.1573
MolecularWeight:517.47
ElementalAnalysis:C,55.71;H,4.29;F,11.01;N,13.53;O,15.46

Synonym:RXDX-105;RXDX105;RXDX105;CEP32496;CEP-32496;CEP32496;AC013773;AC013773;AC-013773.Agerafenib

IUPAC/ChemicalName:1-(3-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea

InChiKey:DKNUPRMJNUQNHR-UHFFFAOYSA-N

InChiCode:InChI=1S/C24H22F3N5O5/c1-23(2,24(25,26)27)19-11-20(32-37-19)31-22(33)30-13-6-5-7-14(8-13)36-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,32,33)

SMILESCode:O=C(NC1=NOC(C(C)(C)C(F)(F)F)=C1)NC2=CC=CC(OC3=C4C=C(OC)C(OC)=CC4=NC=N3)=C2

TechnicalData

Appearance:

Whitetooff-whitesolidpowder

Purity:

>98%(orrefertotheCertificateofAnalysis)

CertificateofAnalysis:

ViewCoA:currentbatch,Lot#TZC60222

QCData:

ViewQCdata:currentbatch,Lot#TZC60222

SafetyDataSheet(MSDS):

ViewMaterialSafetyDataSheet(MSDS)

ShippingCondition:

Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:

Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:

SolubleinDMSO,notinwater

ShelfLife:

>2yearsifstoredproperly

DrugFormulation:

ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:

0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:

293490

AdditionalInformation

RelatedCAS#
CAS#1188910-76-0(freebase)
CAS#1227678-26-3(HClsalt).

References

1:JamesJ,RuggeriB,ArmstrongRC,RowbottomMW,Jones-BolinS,GunawardaneRN,DobrzanskiP,GardnerMF,ZhaoH,CramerMD,HunterK,NepomucenoRR,ChengM,GitnickD,YazdanianM,InskoDE,AtorMA,ApuyJL,FaraoniR,DorseyBD,WilliamsM,BhagwatSS,HolladayMW.CEP-32496:anovelorallyactiveBRAF(V600E)inhibitorwithselectivecellularandinvivoantitumoractivity.MolCancerTher.2012Apr;11(4):930-41.doi:10.1158/1535-7163.MCT-11-0645.Epub2012Feb7.PubMedPMID:22319199.

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MedKoo Biosciences/RXDX105 (CEP32496)/205903/5mg

TechnicalData

AdditionalInformation

References