MedKoo Biosciences/Calpeptin/510332/200mg

Synonym:Calpeptin;Benzylcarbonyl-leu-nleu-H;N-Cbz-leu-nleu-al.

IUPAC/ChemicalName:benzyl((S)-4-methyl-1-oxo-1-(((S)-1-oxohexan-2-yl)amino)pentan-2-yl)carbamate

InChiKey:PGGUOGKHUUUWAF-ROUUACIJSA-N

InChiCode:InChI=1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1

SMILESCode:O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C=O)CCCC)=O)CC(C)C

TechnicalData

AdditionalInformation

References

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4:TabataC,TabataR,NakanoT.Thecalpaininhibitorcalpeptinpreventsbleomycin-inducedpulmonaryfibrosisinmice.ClinExpImmunol.2010Dec;162(3):560-7.doi:10.1111/j.1365-2249.2010.04257.x.Epub2010Sep15.PubMedPMID:20846163;PubMedCentralPMCID:PMC3026560.

5:GuytonMK,DasA,SamantarayS,WallaceGC4th,ButlerJT,RaySK,BanikNL.Calpeptinattenuatedinflammation,celldeath,andaxonaldamageinanimalmodelofmultiplesclerosis.JNeurosciRes.2010Aug15;88(11):2398-408.doi:10.1002/jnr.22408.PubMedPMID:20623621;PubMedCentralPMCID:PMC3164817.

6:PengS,KuangZ,ZhangY,XuH,ChengQ.TheprotectiveeffectsandpotentialmechanismofCalpaininhibitorCalpeptinagainstfocalcerebralischemia-reperfusioninjuryinrats.MolBiolRep.2011Feb;38(2):905-12.doi:10.1007/s11033-010-0183-2.Epub2010May16.PubMedPMID:20473717.

7:GwozdzAM,LeungR,WangH,BangKW,PackhamMA,FreedmanJ,RandML.CalpaininhibitionbycalpeptindoesnotpreventAPLTactivityreductioninPS-exposingplatelets,butcalpeptinhasindependentpro-apoptoticeffects.ThrombHaemost.2010Jun;103(6):1218-27.doi:10.1160/TH09-08-0557.Epub2010Mar29.PubMedPMID:20352156.

8:LinIJ,ZhouZ,Crusselle-DavisVJ,MoghimiB,GandhiK,AnantharamanA,PanticD,HuangS,JayandharanG,ZhongL,SrivastavaA,BungertJ.Calpeptinincreasestheactivityofupstreamstimulatoryfactorandinduceshighlevelglobingeneexpressioninerythroidcells.JBiolChem.2009Jul24;284(30):20130-5.doi:10.1074/jbc.M109.001461.Epub2009Jun2.PubMedPMID:19491096;PubMedCentralPMCID:PMC2740439.

9:ManiSK,ShiraishiH,BalasubramanianS,YamaneK,ChellaiahM,CooperG,BanikN,ZileMR,KuppuswamyD.Invivoadministrationofcalpeptinattenuatescalpainactivationandcardiomyocytelossinpressure-overloadedfelinemyocardium.AmJPhysiolHeartCircPhysiol.2008Jul;295(1):H314-26.doi:10.1152/ajpheart.00085.2008.Epub2008May16.PubMedPMID:18487434;PubMedCentralPMCID:PMC2494745.

10:KookSH,ChoiKC,SonYO,LeeKY,HwangIH,LeeHJ,ChungWT,LeeCB,ParkJS,LeeJC.Involvementofp38MAPK-mediatedsignalinginthecalpeptin-mediatedsuppressionofmyogenicdifferentiationandfusioninC2C12cells.MolCellBiochem.2008Mar;310(1-2):85-92.Epub2007Dec4.PubMedPMID:18057999.