MedKoo Biosciences/WntC59/406605/50mg

Wnt-C59isapotentporcupine(PORCN)inhibitor.Wnt-C59inhibitsPORCNactivityinvitroatnanomolarconcentrations,asassessedbyinhibitionofWntpalmitoylation,WntinteractionwiththecarrierproteinWntless/WLS,Wntsecretion,andWntactivationofβ-cateninreporteractivity.Inmice,Wnt-C59displayedgoodbioavailability,asoncedailyoraladministrationwassufficienttomaintainbloodconcentrationswellabovetheIC(50).C59blockedprogressionofmammarytumorsinMMTV-WNT1transgenicmicewhiledownregulatingWnt/β-catenintargetgenes.Porcupine(PORCN)isamembraneboundO-acyltransferasethatisrequiredforWntpalmitoylation,secretion,andbiologicactivity.

MedKooCat#:406605
Name:Wnt-C59
CAS#:1243243-89-1
ChemicalFormula:C25H21N3O
ExactMass:379.16846
MolecularWeight:379.45
ElementalAnalysis:C,79.13;H,5.58;N,11.07;O,4.22

Synonym:WntC59;Wnt-C59;Wnt-C59

IUPAC/ChemicalName:2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide

InChiKey:KHZOJCQBHJUJFY-UHFFFAOYSA-N

InChiCode:InChI=1S/C25H21N3O/c1-18-15-22(12-14-27-18)20-6-4-19(5-7-20)16-25(29)28-24-10-8-21(9-11-24)23-3-2-13-26-17-23/h2-15,17H,16H2,1H3,(H,28,29)

SMILESCode:O=C(NC1=CC=C(C2=CC=CN=C2)C=C1)CC3=CC=C(C4=CC(C)=NC=C4)C=C3

TechnicalData

Appearance:

Whitetooff-whitesolidpowder

Purity:

>98%(orrefertotheCertificateofAnalysis)

CertificateofAnalysis:

ViewCoA:currentbatch,Lot#CRB50618

QCData:

ViewQCdata:currentbatch,Lot#CRB50618

SafetyDataSheet(MSDS):

ViewMaterialSafetyDataSheet(MSDS)

ShippingCondition:

Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:

Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:

SolubleinDMSO,notinwater

ShelfLife:

>2yearsifstoredproperly

DrugFormulation:

ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:

0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:

293490

References

1:WangB,ZouQ,SunM,ChenJ,WangT,BaiY,ChenZ,ChenB,ZhouM.ReversionoftrichostatinAresistanceviainhibitionoftheWntsignalingpathwayinhumanpancreaticcancercells.OncolRep.2014Nov;32(5):2015-22.doi:10.3892/or.2014.3476.Epub2014Sep10.PubMedPMID:25224651.

2:Bengoa-VergnioryN,GorroÃ±o-EtxebarriaI,GonzÃ¡lez-SalazarI,KyptaRM.Aswitchfromcanonicaltononcanonicalwntsignalingmediatesearlydifferentiationofhumanneuralstemcells.StemCells.2014Dec;32(12):3196-208.doi:10.1002/stem.1807.PubMedPMID:25100239.

3:ProffittKD,MadanB,KeZ,PendharkarV,DingL,LeeMA,HannoushRN,VirshupDM.PharmacologicalinhibitionoftheWntacyltransferasePORCNpreventsgrowthofWNT-drivenmammarycancer.CancerRes.2013Jan15;73(2):502-7.doi:10.1158/0008-5472.CAN-12-2258.Epub2012Nov27.PubMedPMID:23188502.

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MedKoo Biosciences/WntC59/406605/50mg

TechnicalData

References