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MedKoo Biosciences/SP2509/406610/100mg
SP-2509isanovelhistonedemethylaseLSD1inhibitor,whichshowedhighactitivityonhumanAMLcells.TreatmentwiththenovelLSD1antagonistSP2509attenuatedthebindingofLSD1withthecorepressorCoREST,increasedthepermissiveH3K4Me3markonthetargetgenepromoters,andincreasedthelevelsofp21,p27andCCAAT/enhancerbindingproteinαinculturedAMLcells.Inaddition,SP2509treatmentorLSD1shRNAinhibitedthecolonygrowthofAMLcells.

MedKooCat#:406610
Name:SP-2509
CAS#:1423715-09-6
ChemicalFormula:C19H20ClN3O5S
ExactMass:437.08122
MolecularWeight:437.9
ElementalAnalysis:C,52.11;H,4.60;Cl,8.10;N,9.60;O,18.27;S,7.32


Synonym:SP2509;SP2509;SP-2509.

IUPAC/ChemicalName:(E)-N-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide.

InChiKey:NKUDGJUBIVEDTF-FYJGNVAPSA-N

InChiCode:InChI=1S/C19H20ClN3O5S/c1-13(17-12-15(20)5-6-18(17)24)21-22-19(25)14-3-2-4-16(11-14)29(26,27)23-7-9-28-10-8-23/h2-6,11-12,24H,7-10H2,1H3,(H,22,25)/b21-13+

SMILESCode:O=C(N/N=C(C1=CC(Cl)=CC=C1O)C)C2=CC=CC(S(=O)(N3CCOCC3)=O)=C2


TechnicalData

Appearance:
Solidpowder

Purity:
>98%(orrefertotheCertificateofAnalysis)

CertificateofAnalysis:
ViewCoA:currentbatch,Lot#CRB61017

QCData:
ViewQCdata:currentbatch,Lot#CRB61017

SafetyDataSheet(MSDS):
ViewMaterialSafetyDataSheet(MSDS)

ShippingCondition:
Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:
Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:
SolubleinDMSO,notinwater

ShelfLife:
>2yearsifstoredproperly

DrugFormulation:
ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:
0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:
293490


AdditionalInformation

  
 
 
 


References

 1:FiskusW,SharmaS,ShahB,PortierBP,DevarajSG,LiuK,IyerSP,BearssD, BhallaKN.HighlyeffectivecombinationofLSD1(KDM1A)antagonistandpan-histonedeacetylaseinhibitoragainsthumanAMLcells.Leukemia.2014Nov;28(11):2155-64.doi:10.1038/leu.2014.119.Epub2014Apr4.PubMedPMID:24699304.


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