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MedKoo Biosciences/AG-120 (racemic)/206148/5g
206148-5g5gmedkoobiosciencesincMedKoo Biosciences, IncMedKoo Biosciences/AG-120 ...
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406569-2g2gmedkoobiosciencesincMedKoo Biosciences, IncMedKoo Biosciences/P22077/...
MedKoo是世界领先的供应商之一的抗癌化学试剂和激酶抑制剂。我们制造、销售和分发高质量的抗癌小分子肿瘤学研究试剂。我们的使命是建立世界上最全面的抗癌小分子的集合。我们也为医药行业提供高质量的研究服务、医学研究机构和学术机构。我们致力于提供优质的服务和分子有竞争力的价格。MedKoo是您可靠的合作伙伴采购药物发现和药物分子。
Supinoxin,alsoknownasRX-5902,isorallybioavailablesmallmoleculeinhibitorofphosphorylated-p68RNAhelicase(P-p68),withpotentialanti-proliferativeandantineoplasticactivity.Uponoraladministration,P-p68inhibitorRX-5902maybothinhibittheactivityoftheanti-apoptoticB-celllymphoma2(Bcl-2)proteinandfacilitatetheinductionofcyclin-dependentkinaseinhibitor1(p21).ThismaypreventG2/Mcellcycleprogressionandleadtogrowthinhibitionintumorcells.P-p68isoverexpressedinvarioustypesofsolidtumorsbutabsentinnormaltissues,andplaysaroleintumorprogressionandmetastasis.MedKooCat#:206091
Name:Supinoxin(RX-5902)
CAS#:888478-45-3
ChemicalFormula:C22H24FN5O4
ExactMass:441.18123
MolecularWeight:441.46
ElementalAnalysis:C,59.86;H,5.48;F,4.30;N,15.86;O,14.50
Synonym:Supinoxin;RX5902;RX5902;RX5902.
IUPAC/ChemicalName:4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide
InChiKey:KAKPGJJRYRYSTP-UHFFFAOYSA-N
InChiCode:InChI=1S/C22H24FN5O4/c1-30-16-11-15(12-17(13-16)31-2)27-6-8-28(9-7-27)22(29)26-20-21(32-3)25-18-5-4-14(23)10-19(18)24-20/h4-5,10-13H,6-9H2,1-3H3,(H,24,26,29)
SMILESCode:O=C(N1CCN(C2=CC(OC)=CC(OC)=C2)CC1)NC3=NC4=CC(F)=CC=C4N=C3OC
1:KostGC,YangMY,LiL,ZhangY,LiuCY,KimDJ,AhnCH,LeeYB,LiuZR.ANovelAnti-CancerAgent,1-(3,5-Dimethoxyphenyl)-4-[(6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl]piperazine(RX-5902),Interfereswithβ-CateninFunctionthroughY593phospho-p68RNAHelicase.JCellBiochem.2015Feb3.doi:10.1002/jcb.25113.[Epubaheadofprint]PubMedPMID:25649741.
MedKoo Biosciences/Icotinib HCl/205847/1g MedKoo Biosciences/PF-573228/406126/2g MedKoo Biosciences/Mubritinib/206800/5g MedKoo Biosciences/Fostamatinib sodium...
MedKoo是世界的抗癌化学试剂和激酶抑制剂供应商之一。 我们制造,销售和分销用于肿瘤学研究的高质量抗癌小分子试剂。 我们的使命是建立世界上全面的抗癌小分子集合。 我们还为...