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MedKooCat#:205990
Name:Radotinib
CAS#:926037-48-1
ChemicalFormula:C27H21F3N8O
ExactMass:530.17904
MolecularWeight:530.5
ElementalAnalysis:C,61.13;H,3.99;F,10.74;N,21.12;O,3.02
Synonym:IY5511;IY-5511;IY5511;IY5511HCl;Radotinib;tradenameSupect.
IUPAC/ChemicalName:4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzamide
InChiKey:DUPWHXBITIZIKZ-UHFFFAOYSA-N
InChiCode:InChI=1S/C27H21F3N8O/c1-16-3-4-18(9-23(16)37-26-33-6-5-22(36-26)24-13-31-7-8-32-24)25(39)35-20-10-19(27(28,29)30)11-21(12-20)38-14-17(2)34-15-38/h4-15H,1-2H3,(H,35,39)(H,33,36,37)
SMILESCode:O=C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=NC=CN=C5)=N4)=C3
Radotinib(INN;tradenameSupect)isadrugforthetreatmentofsometypesofcancer.ItisapprovedinKoreaforuseasasecond-linetreatmentofchronicmyeloidleukemia(CML).ItsmechanismofactioninvolvesinhibitionofthetyrosinekinaseBcr-Ablandofplatelet-derivedgrowthfactorreceptor(PDGFR).(http://en.wikipedia.org/wiki/Radotinib).
Thechemicalstructureofradotinibisverysimilartoimatinib.(seethefollowinggraphic)
Sidebysidecomparisonofchemicalstructuresbetweenradotinibandimatinib
1:KimSH,MenonH,JootarS,SaikiaT,KwakJY,SohnSK,ParkJS,JeongSH,Kim HJ,KimYK,OhSJ,KimH,ZangDY,ChungJS,ShinHJ,DoYR,KimJA,KimDY,ChoiCW,ParkS,ParkHL,LeeGY,ChoDJ,ShinJS,KimDW.EfficacyandsafetyofradotinibinchronicphasechronicmyeloidleukemiapatientswithresistanceorintolerancetoBCR-ABL1tyrosinekinaseinhibitors.Haematologica.2014Apr4.[Epubaheadofprint]PubMedPMID:24705186.