MedKoo Biosciences/JNJ28312141/406201/1g

JNJ-28312141isanorallyactiveCSF1Rinhibitor(Colony-stimulatingfactor-1receptor,CRF1R)andalsoaFLT3inhibitor.CSF1Risexpressedbymanytumorsandisagrowthfactorformacrophagesandmediatesosteoclastdifferentiation.JNJ-28312141representsanewagentwithpotentialtherapeuticactivityinacutemyeloidleukemiaandinsettingswhereCSF-1-dependentmacrophagesandosteoclastscontributetotumorgrowthandskeletalevents.

MedKooCat#:406201
Name:JNJ-28312141
CAS#:885692-52-4
ChemicalFormula:C26H32N6O2
ExactMass:460.25867
MolecularWeight:460.57
ElementalAnalysis:C,67.80;H,7.00;N,18.25;O,6.95

Synonym:JNJ28312141;JNJ28312141;JNJ-28312141.

IUPAC/ChemicalName:4-cyano-N-(5-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-2,3,4,5-tetrahydro-[1,1-biphenyl]-2-yl)-1H-imidazole-2-carboxamide

InChiKey:GUBJNPWVIUFSTR-UHFFFAOYSA-N

InChiCode:InChI=1S/C26H32N6O2/c1-31(2)17-24(33)32-12-10-18(11-13-32)20-8-9-23(22(14-20)19-6-4-3-5-7-19)30-26(34)25-28-16-21(15-27)29-25/h6,8-9,14,16,18H,3-5,7,10-13,17H2,1-2H3,(H,28,29)(H,30,34)

SMILESCode:O=C(C1=NC(C#N)=CN1)NC2=CC=C(C3CCN(C(CN(C)C)=O)CC3)C=C2C4=CCCCC4

TechnicalData

Appearance:

Solidpowder

Purity:

>98%

ShippingCondition:

Shippedunderambienttemperatureasnon-hazardouschemical.ThisproductisstableenoughforafewweeksduringordinaryshippingandtimespentinCustoms.

StorageCondition:

Dry,darkandat0-4Cforshortterm(daystoweeks)or-20Cforlongterm(monthstoyears).

Solubility:

SolubleinDMSO,notinwater

ShelfLife:

>5yearsifstoredproperly

DrugFormulation:

ThisdrugmaybeformulatedinDMSO

StockSolutionStorage:

0-4Cforshortterm(daystoweeks),or-20Cforlongterm(months).

HarmonizedSystemCode:

293490

AdditionalInformation

References

1:IlligCR,MantheyCL,WallMJ,MeegallaSK,ChenJ,WilsonKJ,BallentineSK, DesjarlaisRL,SchubertC,CryslerCS,ChenY,MolloyCJ,ChaikinMA,DonatelliRR,YurkowE,ZhouZ,PlayerMR,TomczukBE.Optimizationofapotentclassofarylamidecolony-stimulatingfactor-1receptorinhibitorsleadingtoanti-inflammatoryclinicalcandidate4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide(JNJ-28312141).JMedChem.2011Nov24;54(22):7860-83.doi:10.1021/jm200900q.Epub2011Oct31.PubMedPMID:22039836.

2:MantheyCL,JohnsonDL,IlligCR,TumanRW,ZhouZ,BakerJF,ChaikinMA,DonatelliRR,FranksCF,ZengL,CryslerC,ChenY,YurkowEJ,BoczonL,MeegallaSK,WilsonKJ,WallMJ,ChenJ,BallentineSK,OttH,BaumannC,LawrenceD,TomczukBE,MolloyCJ.JNJ-28312141,anovelorallyactivecolony-stimulatingfactor-1receptor/FMS-relatedreceptortyrosinekinase-3receptortyrosinekinaseinhibitorwithpotentialutilityinsolidtumors,bonemetastases,andacutemyeloidleukemia.MolCancerTher.2009Nov;8(11):3151-61.doi:10.1158/1535-7163.MCT-09-0255.Epub2009Nov3.PubMedPMID:19887542.

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MedKoo Biosciences/JNJ28312141/406201/1g

TechnicalData

AdditionalInformation

References