MedKoo Biosciences/Atamestane/200330/10mg

Synonym:Atamestanum;Atamestano;Biomed777;CCRIS6528;SH489;SH-489;SH489

IUPAC/ChemicalName:(8R,9S,10S,13S,14S)-1,10,13-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-3H-cyclopenta[a]phenanthrene-3,17(6H)-dione

InChiKey:PEPMWUSGRKINHX-TXTPUJOMSA-N

InChiCode:InChI=1S/C20H26O2/c1-12-10-14(21)11-13-4-5-15-16-6-7-18(22)19(16,2)9-8-17(15)20(12,13)3/h10-11,15-17H,4-9H2,1-3H3/t15-,16-,17-,19-,20-/m0/s1

SMILESCode:O=C(C=C1CC[C@@]2([H])[C@]3([H])CC4)C=C(C)[C@]1(C)[C@@]2([H])CC[C@]3(C)C4=O

TechnicalData

AdditionalInformation

References

 1:GossPE,QiS,HuH.Comparingtheeffectsofatamestane,toremifeneandtamoxifenaloneandincombination,onbone,serumlipidsanduterusinovariectomizedrats.JSteroidBiochemMolBiol.2009Feb;113(3-5):233-40.doi:10.1016/j.jsbmb.2009.01.005.Epub2009Jan20.PubMedPMID:19429427.

2:GossP,BondarenkoIN,ManikhasGN,PendergrassKB,MillerWHJr,LangeckerP,BlanchettD.PhaseIII,double-blind,controlledtrialofatamestaneplustoremifenecomparedwithletrozoleinpostmenopausalwomenwithadvancedreceptor-positivebreastcancer.JClinOncol.2007Nov1;25(31):4961-6.PubMedPMID:17971594.

3:SabnisGJ,MacedoL,GoloubevaO,SchayowitzA,ZhuY,BrodieA.Toremifene-atamestane;aloneorincombination:predictionsfromthepreclinicalintratumoralaromatasemodel.JSteroidBiochemMolBiol.2008Jan;108(1-2):1-7.Epub2007Sep7.PubMedPMID:17942301;PubMedCentralPMCID:PMC3081608.

4:SantenRJ,DemersL,OhorodnikS,SettlageJ,LangeckerP,BlanchettD,GossPE,WangS.Superiorityofgaschromatography/tandemmassspectrometryassay(GC/MS/MS)forestradiolformonitoringofaromataseinhibitortherapy.Steroids.2007Jul;72(8):666-71.Epub2007May21.PubMedPMID:17588628.

5:GossPE,QiS,HuH,CheungAM.Theeffectsofatamestaneandtoremifenealoneandincombinationcomparedwithletrozoleonbone,serumlipidsandtheuterusinanovariectomizedratmodel.BreastCancerResTreat.2007Jul;103(3):293-302.Epub2006Oct25.PubMedPMID:17063268.

6:MullerM,vandenBeldAW,vanderSchouwYT,GrobbeeDE,LambertsSW.Effectsofdehydroepiandrosteroneandatamestanesupplementationonfrailtyinelderlymen.JClinEndocrinolMetab.2006Oct;91(10):3988-91.Epub2006Jun27.PubMedPMID:16804050.

7:ItoK,FukaboriY,ShibataY,SuzukiK,MiedaM,GotandaK,HonmaS,YamanakaH.Effectsofanewsteroidalaromataseinhibitor,TZA-2237,and/orchlormadinoneacetateonhormone-inducedandspontaneouscaninebenignprostatichyperplasia.EurJEndocrinol.2000Oct;143(4):543-54.PubMedPMID:11022202.

8:HaradaN,HondaSI,HatanoO.Aromataseinhibitorsandenzymestability.EndocrRelatCancer.1999Jun;6(2):211-8.PubMedPMID:10731111.

9:SteckelbroeckS,HeidrichDD,Stoffel-WagnerB,HansVH,SchrammJ,BidlingmaierF,KlingmüllerD.CharacterizationofaromatasecytochromeP450activityinthehumantemporallobe.JClinEndocrinolMetab.1999Aug;84(8):2795-801.Erratumin:JClinEndocrinolMetab1999Dec;84(12):4606.PubMedPMID:10443682.

10:BoehmS,NirnbergerG,FerrariP.Estrogensuppressionasapharmacotherapeuticstrategyinthemedicaltreatmentofbenignprostatichyperplasia:evidenceforitsefficacyfromstudieswithmepartricin.WienKlinWochenschr.1998Dec11;110(23):817-23.Review.PubMedPMID:10025034.