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We believe that all successful projects start with great project design. This is where we excel. Using our NeoAb® bioinformatics approach, we help clients define a project that has the best chance of success in making antibodies that will meet their needs - in terms of both specificity and sensitivity.
In addition to some basic information needed from our clients (protein sequence, desired end use of the antibody), we help determine:
Based on the answers to these questions as well as others, we can design a project approach to minimize the inherent risk in antibody development, while at the same time increasing the chances of developing highly specific & sensitive antibodies of interest.
Because NeoClone is adept at both antibody phage display technology AND traditional hybridoma technology, we can help you decide which approach will work best for your needs.
Do you have a target of interest to which you would like NeoClone to apply its bioinformatic approach? Please contact us to begin the process.
苏州蚂蚁淘生物科技有限公司成立于2017年，是一家专业提供实验室整体采购方案的专业公司，为广大采购和实验室解决了大量问题，几年来已经成为所有合作伙伴最优秀的合作伙伴，我们一直秉承信誉第一的原则，坚持不卖假货，哪怕利润损失也要为客户提供最好的产品
我们已经和国外500多个品牌建立了贸易往来，并在国际上享有相当知名度，现已经成为国外近100多个品牌中国指定代理，并成为其中国最优秀的代理商
热心细致的服务态度打造温暖亲切的购物氛围，有任何问题欢迎随时联系我们！苏州蚂蚁淘生物科技有限公司SuZhouebiomall BIOLOGicalTechnologyCo.,Ltd.总部地址:苏州园区星湖街218号苏州生物医药产业园一期（生物纳米园）A4-216服务热线:4000-520-616（限工作日9:00-18:00）固话：0512-67156496手机：18915418616QQ：3507623898、3464842061、1570468124传真:0512-67226173Email:info@ebiomall.com
Antibody Phage Display (scFv) NeoClone is a world-class custom antibody development company, having discovered hundreds of antibodies for our clients. But there are very difficult targets out there that hybridoma technology alone can’t solve. So we added antibody phage display capabilities to help us develop the diverse and specific antibody repertoire to difficult targets that you need. Our team now has over 15 years of scFv phage antibody and recombinant antibody experience. Greater Diversity, Faster Answers One of the advantages of phage display is the enormous diversity of variant antibody genes that can be represented in a phage library, even to relatively non-immunogenic targets. NeoClone’s antibody phage display service provides a means of rapidly screening large numbers of scFv in our antibody gene libraries against potential binding partners in only 2 weeks. Once promising clones are identified, we can clone, express and sequence the scFv antibodies for your further evaluation. Based on your needs, we can engineer the antibody further for expression in mammalian cells, affinity maturation or other optimization steps. NeoClone can also construct new scFv phage libraries from immunized or naïve donors from several species. Antibody Phage Display Screening NeoClone's proprietary antibody phage display screening method allows for efficient, high throughput identification of rare binders with distinctive characteristics required for a specific application. NeoClone is able to generate scFv antibodies that target antigens that have traditionally been difficult to attain, including Post-Translationally Modified peptides (PTMs) such as acetylated or phosphorylated antigens. In addition, NeoClone can express the specific phage as scFv-Fc in mammalian cell culture or by periplasmic expression in bacteria. The image below shows the results of screening for a phospho-peptide specific scFv in one of our antibody phage display libraries. Four individual clones recognized the phospho-peptide (P-Myb) but not the un-phosphorylated peptide (Myb). Antibody Phage Display Library Construction How does that work? Click on the image below for an overview. C. M. Hammers & J. R. Stanley, Journal of Investigative Dermatology (2013) 134, e17. doi:10.1038/jid.2013.521 If you are interested in starting an antibody project with NeoClone, please contact us. Additional references can be found here and here.