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| Details: | |
| Tested Applications | ELISA, WB |
| Target Information | Murine FBXL5 is a 77.9kDa protein that plays a central role in iron homeostasis. |
| Product Format | Affinity Purified |
| Alternate Names | F-box/LRR-repeat protein 5, F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, p45SKP2-like protein, FBL4, FBL5, FLR1 |
| Clone | 3F5G12G9 |
| Host | Mouse |
| Isotype | IgG2b |
| Immunogen | Recombinant Protein |
| Epitope | Unknown |
| Relevance | Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued |
| Specificity | Mouse |
| Reported Reactivity | Unknown |
| Reported Applications | Unknown |
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