Details: | |
Tested Applications | ELISA, WB |
Target Information | Murine FBXL5 is a 77.9kDa protein that plays a central role in iron homeostasis. |
Product Format | Affinity Purified |
Alternate Names | F-box/LRR-repeat protein 5, F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, p45SKP2-like protein, FBL4, FBL5, FLR1 |
Clone | 3F5G12G9 |
Host | Mouse |
Isotype | IgG2b |
Immunogen | Recombinant Protein |
Epitope | Unknown |
Relevance | Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued |
Specificity | Mouse |
Reported Reactivity | Unknown |
Reported Applications | Unknown |
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